This article is dedicated to the memory of Prof. Gregorio Montes (University of Sao Paulo, Brazil) who was a devoted “fin regenerationist” and died prematurely.
Old questions, new tools, and some answers to the mystery of fin regeneration†
Article first published online: 22 JAN 2003
Copyright © 2003 Wiley-Liss, Inc.
Special Issue: Regeneration Special Issue
Volume 226, Issue 2, pages 190–201, February 2003
How to Cite
Akimenko, M.-A., Marí-Beffa, M., Becerra, J. and Géraudie, J. (2003), Old questions, new tools, and some answers to the mystery of fin regeneration. Dev. Dyn., 226: 190–201. doi: 10.1002/dvdy.10248
- Issue published online: 28 JAN 2003
- Article first published online: 22 JAN 2003
- Manuscript Accepted: 19 NOV 2002
- Manuscript Received: 4 NOV 2002
- Canadian Institutes of Health Research. Grant Number: MT-11775
- DGESC. Grant Number: PB98-1409
- Junta de Andalucía. Grant Number: Grupo CVI217
- CNRS-UMR. Grant Number: 7052
- bony rays;
Pluridisciplinary approaches led to the notion that fin regeneration is an intricate phenomenon involving epithelial–mesenchymal and reciprocal exchanges throughout the process as well as interactions between ray and interray tissue. The establishment of a blastema after fin amputation is the first event leading to the reconstruction of the missing part of the fin. Here, we review our knowledge on the origin of the blastema, its formation and growth, and of the mechanisms that control differentiation and patterning of the regenerate. Our current understanding results from studies of fin regeneration performed in various teleost fish over the past century. We also report the recent breakthroughs that have been made in the past decade with the arrival of a new model, the zebrafish, Danio rerio, which now offers the possibility to combine cytologic, molecular, and genetic analyses and open new perspectives in this field. Developmental Dynamics 226:190–201, 2003. © 2003 Wiley-Liss, Inc.