Patterns & Phenotypes
lunatic fringe regulates delta-notch induction of hypochord in zebrafish
Article first published online: 27 AUG 2003
Copyright © 2003 Wiley-Liss, Inc.
Volume 228, Issue 2, pages 281–286, October 2003
How to Cite
Appel, B., Marasco, P., McClung, L. E. and Latimer, A. J. (2003), lunatic fringe regulates delta-notch induction of hypochord in zebrafish. Dev. Dyn., 228: 281–286. doi: 10.1002/dvdy.10375
- Issue published online: 16 SEP 2003
- Article first published online: 27 AUG 2003
- Manuscript Accepted: 30 JUN 2003
- Manuscript Received: 26 APR 2003
- NIH. Grant Number: HD38118
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch–mediated induction of hypochord cells at the lateral borders of the midline precursor domain. Development Dynamics 228:281–286, 2003. © 2003 Wiley-Liss, Inc.