1097-0177/asset/DVDY_left.gif?v=1&s=b87335326ab8ecd1f573539da0b5fa6abef26532)
Review
T-box genes in early embryogenesis
Article first published online: 10 DEC 2003
DOI: 10.1002/dvdy.10480
Copyright © 2003 Wiley-Liss, Inc.
Issue
Developmental Dynamics
Special Issue: Special Focus on the Neural Crest and the Contributions of James A. Weston
Volume 229, Issue 1, pages 201–218, January 2004
Additional Information
How to Cite
Showell, C., Binder, O. and Conlon, F. L. (2004), T-box genes in early embryogenesis. Dev. Dyn., 229: 201–218. doi: 10.1002/dvdy.10480
Publication History
- Issue published online: 23 DEC 2003
- Article first published online: 10 DEC 2003
- Manuscript Accepted: 9 OCT 2003
- Manuscript Revised: 7 OCT 2003
- Manuscript Received: 23 AUG 2003
Funded by
- American Heart Foundation. Grant Number: 0265382U
- Abstract
- Article
- References
- Cited By
Keywords:
- T-box;
- T-domain;
- Brachyury;
- Eomesodermin;
- VegT;
- spadetail;
- no tail;
- tbx6;
- mesoderm;
- transcription
Abstract
The T-box gene family, encoding related DNA-binding transcriptional regulators, plays an essential role in controlling many aspects of embryogenesis in a wide variety of organisms. The T-box genes exhibit diverse patterns of spatial and temporal expression in the developing embryo, and both genetic and molecular embryological studies have demonstrated their importance in regulating cell fate decisions that establish the early body plan, and in later processes underlying organogenesis. Despite these studies, little is known of either the regulation of the T-box genes or the identities of their transcriptional targets. The aim of this review is to examine the diverse yet conserved roles of several T-box genes in regulating early patterning in chordates and to discuss possible mechanisms through which this functional diversity might arise. Developmental Dynamics 229:201–218, 2004. © 2003 Wiley-Liss, Inc.