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Keywords:

  • Cre recombinase;
  • transgenic mice;
  • hair cells

Abstract

We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell–specific gene targeting. Developmental Dynamics 231:199–203, 2004. © 2004 Wiley-Liss, Inc.