Growth factor-responsive progenitors in the postnatal mammalian retina
Article first published online: 6 JAN 2005
Copyright © 2005 Wiley-Liss, Inc.
Volume 232, Issue 2, pages 349–358, February 2005
How to Cite
Zhao, X., Das, A. V., Soto-Leon, F. and Ahmad, I. (2005), Growth factor-responsive progenitors in the postnatal mammalian retina. Dev. Dyn., 232: 349–358. doi: 10.1002/dvdy.20290
- Issue published online: 13 JAN 2005
- Article first published online: 6 JAN 2005
- Manuscript Accepted: 4 NOV 2004
- Manuscript Revised: 19 OCT 2004
- Manuscript Received: 26 JUL 2004
- NIH (NEI)
- Nebraska Research Initiative and Research to Prevent Blindness
- stem cells
It is thought that the adult mammalian retina lacks the regenerative capacity of fish and amphibians retina because it does not harbor a progenitor population. However, recent observations suggest that another derivative of the optic neuroepithelium, the ciliary body, contains a mitotically quiescent population of neural progenitors that proliferate in the presence of growth factors and demonstrate properties of neural stem cells. Examination of the hypothesis that similar mitotically quiescent and growth factor-responsive progenitors may exist in the postnatal retina revealed a population of cells located in the periphery of the retina that displayed proliferative responsiveness to growth factors and possessed potential to support neurogenesis. Given their marginal position and neural properties and potential, these cells may represent a residual population of retinal progenitors, analogous to those found in the ciliary marginal zone of fish and amphibians. Their progressive decrease in proliferative potential and number in postnatal stages suggests a temporal decline in regulatory signaling that supports their maintenance during retinal neurogenesis. Developmental Dynamics 232:349–358, 2005. © 2005 Wiley-Liss, Inc.