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Multipotent stem cells from adult olfactory mucosa

  1. Wayne Murrell1,‡,*,
  2. François Féron1,†,‡,
  3. Andrew Wetzig1,
  4. Nick Cameron1,
  5. Karisha Splatt1,
  6. Bernadette Bellette1,
  7. John Bianco1,
  8. Chris Perry2,
  9. Gabriel Lee3,
  10. Alan Mackay-Sim1

Article first published online: 21 MAR 2005

DOI: 10.1002/dvdy.20360

Issue

Developmental Dynamics

Developmental Dynamics

Special Issue: Special Focus on Limb Development

Volume 233, Issue 2, pages 496–515, June 2005

Additional Information

How to Cite

Murrell, W., Féron, F., Wetzig, A., Cameron, N., Splatt, K., Bellette, B., Bianco, J., Perry, C., Lee, G. and Mackay-Sim, A. (2005), Multipotent stem cells from adult olfactory mucosa. Dev. Dyn., 233: 496–515. doi: 10.1002/dvdy.20360

Author Information

  1. 1

    Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia

  2. 2

    Department of Otolaryngology, Princess Alexandra Hospital, Brisbane, Australia

  3. 3

    Department of Neurosurgery, Royal Adelaide Hospital, South Australia, Australia

  1. †

    Faculté de Médecine, Université de Marseille, 13385 Marseille Cedex 05, France

  1. ‡

    Drs. Murrell and Féron contributed equally in this work.

*Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111 Australia

Publication History

  1. Issue published online: 12 MAY 2005
  2. Article first published online: 21 MAR 2005
  3. Manuscript Accepted: 27 DEC 2004
  4. Manuscript Received: 20 DEC 2004

Funded by

  • Queensland Health
  • Garnett Passe and Rodney Williams Foundation
  • Stanley Medical Research Institute

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Keywords:

  • neural stem cell;
  • olfactory mucosa;
  • adult;
  • human;
  • rodent

Abstract

Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone marrow–irradiated hosts, and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. Developmental Dynamics 233:496–515, 2005. © 2005 Wiley-Liss, Inc.

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