Drs. Murrell and Féron contributed equally in this work.
Research Article
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Multipotent stem cells from adult olfactory mucosa
Article first published online: 21 MAR 2005
DOI: 10.1002/dvdy.20360
Copyright © 2005 Wiley-Liss, Inc.
Issue

Developmental Dynamics
Special Issue: Special Focus on Limb Development
Volume 233, Issue 2, pages 496–515, June 2005
Additional Information
How to Cite
Murrell, W., Féron, F., Wetzig, A., Cameron, N., Splatt, K., Bellette, B., Bianco, J., Perry, C., Lee, G. and Mackay-Sim, A. (2005), Multipotent stem cells from adult olfactory mucosa. Dev. Dyn., 233: 496–515. doi: 10.1002/dvdy.20360
Publication History
- Issue published online: 12 MAY 2005
- Article first published online: 21 MAR 2005
- Manuscript Accepted: 27 DEC 2004
- Manuscript Received: 20 DEC 2004
Funded by
- Queensland Health
- Garnett Passe and Rodney Williams Foundation
- Stanley Medical Research Institute
REFERENCES
- , , , , , , , . 2003. Plastic adult stem cells: will they graduate from the school of hard knocks? J Cell Sci 116: 599–603.
- , , , , , , , , . 2003. Fusion of bone marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425: 968–973.
- , , . 2001. Can stem cells cross lineage boundaries? Nat Med 7: 393–395.
- , . 2002. Multipotential stem cells in adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol 283: G767–G777.
- , , , , . 1999. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283: 534–537.
- , , . 1994. Globose basal cells are neuronal progenitors in the olfactory epithelium: a lineage analysis using a replication-incompetent retrovirus. Neuron 13: 339–352.
- , . 1989. Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. Neuron 3: 115–127.
- , , . 2004. Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype. J Neurosci 24: 5670–5683.
- , , . 2004. Multipotency of purified, transplanted globose basal cells in olfactory epithelium. J Comp Neurol 469: 457–474.Direct Link:
- , , , , , , , . 2000. Generalized potential of adult neural stem cells. Science 288: 1660–1663.
- , , , , , , . 2004. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 363: 1432–1437.
- , , . 2001. Muscle-derived stem cells: characterization and potential for cell-mediated therapy. Blood Cells Mol Dis 27: 924–933.
- , , . 2001. Expression of the intermediate filament protein nestin by sustentacular cells in mature olfactory neuroepithelium. J Comp Neurol 437: 186–195.Direct Link:
- , , , , , , , , , . 2001. Histone variant H2A.Z is required for early mammalian development. Curr Biol 11: 1183–1187.
- , , , , , . 1999. Stress induces neurogenesis in non-neuronal cell cultures of adult olfactory epithelium. Neuroscience 88: 571–583.
- , , , , . 1999. Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia. Schizophrenia Res. 40: 211–218.
- , , , . 1998. New techniques for biopsy and culture of human olfactory epithelial neurons. Arch Otolaryngol Head Neck Surg 124: 861–866.
- , , , , , , . 2002. Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1alpha and monocyte chemoattractant protein-1. J Neurosci Res 70: 784–793.Direct Link:
- , , , . 1998. Transplantation of multipotent progenitors from the adult olfactory epithelium. Neuroreport 9: 1611–1617.
- , . 1979. Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons. J Neurocytol 8: 1–18.
- , , , , , , , . 2004. Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection. Stem Cells 22: 600–608.Direct Link:
- , , , , , , , , , , . 1996. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci 16: 1091–1100.
- , , , , , . 2004. Lack of fusion requirement for development of bone marrow-derived epithelia. Science 305: 90–93.
- , , , , . 1998. Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. J Comp Neurol 400: 469–486.Direct Link:
- , , , , . 1997. Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. J Invest Dermatol 109: 534–540.
- , , , , , , , , . 1990. RT7-defined alloantigens in rats are part of the leucocyte common antigen family. Scand J Immunol 31: 699–710.Direct Link:
- , . 1975. Immunological studies of the rat olfactory marker protein. J Neurochem 24: 1101–1106.Direct Link:
- , . 1995. Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF. J Neurosci 15: 3653–3661.
- , , , , , , . 1991. Human Cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66: 1217–1228.
- , , , , . 1991. Male development of chromosomally female mice transgenic for Sry. Nature 351: 117–121.
- , , , , , , . 1994. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. Blood 84: 691–701.
- , . 2002. Biological progression from adult bone marrow to mononucleate muscle cell to multinucleate muscle fibre in response to injury. Cell 111: 589–601.
- , , . 1990. CNS stem cells express a new class of intermediate filament protein. Cell 60: 585–595.
- , , , , . 1996. FGF2 promotes neuronal differentiation in explant cultures of adult and embryonic mouse olfactory epithelium. J Neurosci Res 44: 27–39.Direct Link:
- , . 2000. Neurotrophic factors in the primary olfactory pathway. Prog Neurobiol 62: 527–559.
- , . 1991. Cell dynamics in the adult mouse olfactory epithelium: a quantitative autoradiographic study. J Neurosci Res 11: 979–984.
- , . 1993. Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: roles of EGF and TGF-beta s. Neuron 10: 293–305.
- , . 1974. Periodate-lysine-paraformaldehyde fixative a new fixative for immmunoelectron microscopy. J Histochem Cytochem 22: 1077–1083.
- , , , . 1992. Characterization of the immune barrier in human olfactory mucosa. Otolaryngol Head Neck Surg 106: 181–188.
- , . 2004. New insight into progenitor/stem cells in dental pulp using Col1a1-GFP transgenes. Cells Tissues Organs 176: 120–133.
- . 2004. Olfaction targeted. Differentiation 72:Abstract 12.
- , , , . 2002. Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med 8: 268–273.
- , , , , , , . 1996. Neurogenesis in adult human. Neuroreport 7: 1189–1194.
- , , . 1990. Adult cardiac muscle cells in long term serum-free culture: myofibrillar organization and expression of myosin heavy chain isoforms. In Vitro Cell Dev Biol 26: 464–470.
- , , . 2000. Growth factor regulation of neurogenesis in adult olfactory epithelium. Neuroscience 99: 343–350.
- , , , , , , , . 2004. Spontaneous fusion of cells between species yields transdifferentiation and retroviral transfer in vivo. FASEB J 18: 548–550.
- , , . 1995. Is nestin a marker for chemosensory precursor cells? Brain Res 683: 254–257.
- . 1992. CNS glial cells support in vitro survival, division, and differentiation of dissociated olfactory neuronal progenitor cells. Neuron 8: 1191–1204.
- , , , , . 2004. Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion. Proc Natl Acad Sci U S A 101: 9282–9285.
- , . 1992. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255: 1707–1710.
- , , , , , . 2001. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 412: 736–739.
- , , , , , , . 2001. Adult human olfactory stem cells. Brain Res 890: 11–22.
- , . 1975. Parasexual approaches to the genetics of man. Annu Rev Genet 9: 407–486.
- , , , , , . 2001. Identification of a candidate human neurohematopoietic stem-cell population. Blood 98: 2412–2422.
- , , , , . 1999. Adult rat olfactory nerve ensheathing cells are effective promoters of adult central nervous system neurite outgrowth in coculture. Glia 25: 256–269.Direct Link:
- , . 1992. The somitogenetic potential of cells in the primitive streak and the tail bud of the organogenesis-stage mouse embryo. Development 115: 703–715.
- , , , , , , , , , . 1993. Characterization of rat LECAM-1 (L-selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera. Eur J Immunol 23: 2181–2188.Direct Link:
- , , , , . 1989. Characterization of a CD3-like rat T cell surface antigen recognized by a monoclonal antibody. J Immunol 142: 2791–2795.
- , , , , , , , , , . 2002. Bone marrow cells adopt the phenotype of other cells by spontaneous fusion. Nature 416: 542–545.
- , , , , , , . 2001. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3: 778–784.
- , , . 2003. Transplanted bone marrow regenerates liver by cell fusion. Nature 422: 901–904.
- , , , , , , , , , . 2003. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422: 897–901.
- , . 2000. Out of Eden: stem cells and their niches. Science 287: 1427–1430.
- , , , , , , , . 1992. Continuous culture of neuronal cells from adult human olfactory epithelium. J Mol Neurosci 3: 137–146.
- , , , . 1985. Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes. Eur J Immunol 15: 168–173.Direct Link:
- , . 2002. Cell fusion causes confusion. Nature 416: 485–487.
- , , , , , , . 2004. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 430: 350–356.
- , , , . 2002. Changing potency by spontaneous fusion. Nature 416: 545–548.
- , , , , . 2004. Adult human olfactory neural progenitors cultured in defined media. Exp Neurol 186: 112–123.
- , , , , , , , , . 2001. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211–228.

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