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Expression of Xenopus XlSALL4 during limb development and regeneration

  1. Anton W. Neff1,2,*,
  2. Michael W. King2,3,
  3. Mark W. Harty1,†,
  4. Trent Nguyen1,‡,
  5. John Calley4,
  6. Rosamund C. Smith2,4,
  7. Anthony L. Mescher1,2

Article first published online: 20 APR 2005

DOI: 10.1002/dvdy.20363

Issue

Developmental Dynamics

Developmental Dynamics

Special Issue: Special Focus on Limb Development

Volume 233, Issue 2, pages 356–367, June 2005

Additional Information

How to Cite

Neff, A. W., King, M. W., Harty, M. W., Nguyen, T., Calley, J., Smith, R. C. and Mescher, A. L. (2005), Expression of Xenopus XlSALL4 during limb development and regeneration. Dev. Dyn., 233: 356–367. doi: 10.1002/dvdy.20363

Author Information

  1. 1

    Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana

  2. 2

    Center for Regenerative Biology and Medicine, IUPUI, Indianapolis, Indiana

  3. 3

    Terre Haute Center for Medical Education, Indiana University School of Medicine, Terre Haute, Indiana

  4. 4

    Biotechnology Discovery Research, Lilly Research Laboratories, Division of Eli Lilly & Company, Indianapolis, Indiana

  1. †

    Rhode Island Hospital, NAB 220, 593 Eddy Street, Providence, RI 02903

  2. ‡

    UCSF VA Medical Center, Department of Neurology, San Francisco, CA 94121

*Medical Sciences Program, Jordan Hall 204, 1001 E. 3rd Street, Indiana University, Bloomington, IN 47405

Publication History

  1. Issue published online: 12 MAY 2005
  2. Article first published online: 20 APR 2005
  3. Manuscript Accepted: 30 DEC 2004
  4. Manuscript Revised: 29 DEC 2004
  5. Manuscript Received: 20 OCT 2004

Funded by

  • Eli Lilly and Co.
  • Indiana 21st Century Research and Technology Fund
  • National Science Foundation

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Keywords:

  • Xenopus laevis;
  • limb;
  • development;
  • regeneration;
  • SALL4

Abstract

The multi-C2H2 zinc-finger domain containing transcriptional regulators of the spalt (SAL) family plays important developmental regulatory roles. In a competitive subtractive hybridization screen of genes expressed in Xenopus laevis hindlimb regeneration blastemas, we identified a SAL family member that, by phylogenetic analysis, falls in the same clade as human SALL4 and have designated it as XlSALL4. Mutations of human SALL4 have been linked to Okihiro syndrome, which includes preaxial (anterior) limb defects. The expression pattern of XlSALL4 transcripts during normal forelimb and hindlimb development and during hindlimb regeneration at the regeneration-competent and regeneration-incompetent stages is temporally and regionally dynamic. We show for the first time that a SAL family member (XlSALL4) is expressed at the right place and time to play a role regulating both digit identity along the anterior/posterior axis and epimorphic limb regeneration. Developmental Dynamics 233:356–367, 2005. © 2005 Wiley-Liss, Inc.

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