Special Focus Patterns & Phenotypes
Expression of Xenopus XlSALL4 during limb development and regeneration
Article first published online: 20 APR 2005
Copyright © 2005 Wiley-Liss, Inc.
Special Issue: Special Focus on Limb Development
Volume 233, Issue 2, pages 356–367, June 2005
How to Cite
Neff, A. W., King, M. W., Harty, M. W., Nguyen, T., Calley, J., Smith, R. C. and Mescher, A. L. (2005), Expression of Xenopus XlSALL4 during limb development and regeneration. Dev. Dyn., 233: 356–367. doi: 10.1002/dvdy.20363
- Issue published online: 12 MAY 2005
- Article first published online: 20 APR 2005
- Manuscript Accepted: 30 DEC 2004
- Manuscript Revised: 29 DEC 2004
- Manuscript Received: 20 OCT 2004
- Eli Lilly and Co.
- Indiana 21st Century Research and Technology Fund
- National Science Foundation
- Xenopus laevis;
The multi-C2H2 zinc-finger domain containing transcriptional regulators of the spalt (SAL) family plays important developmental regulatory roles. In a competitive subtractive hybridization screen of genes expressed in Xenopus laevis hindlimb regeneration blastemas, we identified a SAL family member that, by phylogenetic analysis, falls in the same clade as human SALL4 and have designated it as XlSALL4. Mutations of human SALL4 have been linked to Okihiro syndrome, which includes preaxial (anterior) limb defects. The expression pattern of XlSALL4 transcripts during normal forelimb and hindlimb development and during hindlimb regeneration at the regeneration-competent and regeneration-incompetent stages is temporally and regionally dynamic. We show for the first time that a SAL family member (XlSALL4) is expressed at the right place and time to play a role regulating both digit identity along the anterior/posterior axis and epimorphic limb regeneration. Developmental Dynamics 233:356–367, 2005. © 2005 Wiley-Liss, Inc.