Special Focus Research Article
Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb
Version of Record online: 20 APR 2005
Copyright © 2005 Wiley-Liss, Inc.
Special Issue: Special Focus on Limb Development
Volume 233, Issue 2, pages 301–312, June 2005
How to Cite
Harduf, H., Halperin, E., Reshef, R. and Ron, D. (2005), Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb. Dev. Dyn., 233: 301–312. doi: 10.1002/dvdy.20364
- Issue online: 12 MAY 2005
- Version of Record online: 20 APR 2005
- Manuscript Accepted: 9 JAN 2005
- Manuscript Revised: 2 JAN 2005
- Manuscript Received: 23 JUN 2004
- Israel Cancer Research Fund. Grant Number: 200701
- Technion-Neidersachsen Foundation. Grant Number: 140-753
- Malat Family Foundation
- 1992. The FGF family of growth factors and oncogenes. Adv Cancer Res 59: 115–165. , .
- 2000. FGF signals for cell proliferation and migration through different pathways. Cytokine Growth Factor Rev 11: 295–302. , , , , , X.
- 2000. Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling. Mech Dev 91: 361–364. , .
- 2003. Split personalities: the agonistic antagonist Sprouty. Nat Cell Biol 5: 377–379. .
- 1995. Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80: 739–746. , , , , .
- 1995. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121: 439–451. , .
- 1996. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84: 127–136. , , , .
- 2003. Negative receptor signalling. Curr Opin Cell Biol 15: 128–135. , .
- 1994. Cell-type-specific nuclear translocation of fibroblast growth factor-2 isoforms during chicken kidney and limb morphogenesis. Dev Biol 163: 316–330. , .
- 2003. Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Curr Biol 13: 1009–1018. , , , , , , , , , .
- 1991. Alternative splicing generates at least five different isoforms of the human basic-FGF receptor. Oncogene 6: 1195–1202. , , , , .
- 1992. bFGF induces its own gene expression in astrocytic and hippocampal cell cultures. Neuroreport 3: 1077–1080. , , , , , .
- 2001. Fibroblast growth factors in the developing central nervous system. Clin Exp Pharmacol Physiol 28: 493–503. , , .
- 2002. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat Cell Biol 4: 170–174. , , , , .
- 1951. A series of normal stages in the development of the chick embryo. J Morphol 88: 49–92. , .
- 1994. Mechanisms of limb patterning. Curr Opin Genet Dev 4: 535–542. , , .
- 2003. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat Cell Biol 5: 513–519. , , , , , , , , , , , , .
- 2003. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J Biol Chem 278: 14087–14091. , , , , .
- 2004. Expression of fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. Gene Expression Patterns 4: 687–693. , , , , , .
- 1994. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79: 993–1003. , , , , .
- 2000. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26: 460–463. , , .
- 2002. Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Mech Dev 113: 163–168. , , , , , .
- 2003. Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development 130: 2213–2224. , , , , , , .
- 1999. p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation. J Biol Chem 274: 17491–17498. .
- 1995. A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol 5: 797–806. , , , , , , , , , .
- 1997. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell 89: 139–148. , , , , , .
- 1998. The roles of FGFs in the early development of vertebrate limbs. Genes Dev 12: 1571–1586. .
- 2000. Vertical regulation of En-2 expression and eye development by FGFs and BMPs. J Craniofac Genet Dev Biol 20: 64–75. , .
- 1998. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12: 3156–3161. , , , , , , , .
- 1999. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development 126: 4465–4475. , , , , , , , .
- 2001. Role of FGFs in the control of programmed cell death during limb development. Development 128: 2075–2084. , , , , , , , , .
- 2000. Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 26: 455–459. , .
- 2000. Normal limb development in conditional mutants of Fgf4. Development 127: 989–996. , , .
- 1995. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev 9: 2911–2922. , , , , .
- 2002. Modular feedback. Nature 417: 35–36. , .
- 2003. Pattern formation: old models out on a limb. Nat Rev Genet 4: 133–143. .
- 1993. FGF-4 regulates expression of Evx-1 in the developing mouse limb. Development 119: 287–294. , .
- 1993. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75: 579–587. , , , , .
- 1994. Expression patterns of two fibroblast growth factor receptor genes during early chick eye development. Exp Eye Res 58: 649–658. , , , , , , , , .
- 2001. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A 98: 6074–6079. , , , , , .
- 2001. Fibroblast growth factors. Genome Biol 2: REVIEWS3005. , .
- 1999. BMPs negatively regulate structure and function of the limb apical ectodermal ridge. 126: 883–894. , .
- 2002. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem Pharmacol 64: 755–763. , , .
- 2000. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 7: 165–197. , , .
- 2004. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proc Natl Acad Sci U S A 101: 1229–1234. , , , , , , , .
- 1995. Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities. J Biol Chem 270: 29813–29818. , , , , .
- 1993. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75: 1401–1416. , , , .
- 1995. FGF-2 mRNA and its antisense message are expressed in a developmentally specific manner in the chick limb bud and mesonephros. Dev Dyn 202: 343–353. , .
- 1993. Distribution of FGF-2 suggests it has a role in chick limb bud growth. Dev Dyn 198: 159–170. , , , , , .
- 1999. Fgf10 is essential for limb and lung formation. Nat Genet 21: 138–141. , , , , , , , , , , .
- 1999. Expression of Fgf4 during early development of the chick embryo. Mech Dev 85: 189–192. , .
- 1995. Fibroblast growth factor receptors display both common and distinct signaling pathways. Oncogene 10: 1553–1561. , , , .
- 1999. Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs. J Biol Chem 274: 35016–35022. , , , , , , .
- 1973. A description of chick wing bud development and a model of limb morphogenesis. Dev Biol 33: 138–153. , .
- 2002. Spatial and temporal pattern of Fgf-8 expression during chicken development. Anat Embryol (Berl) 205: 1–6. , , .
- 1974. A quantitative analysis of the effect of excision of the AER from the chick limb-bud. J Embryol Exp Morphol 32: 651–660. .
- 1973. Positional information in chick limb morphogenesis. Nature 244: 492–496. , , .
- 2000. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 25: 83–86. , , , , , .
- 2002. Molecular basis of vertebrate limb patterning. Am J Med Genet 112: 250–255. .
- 2001. Vertebrate limb development—the early stages in chick and mouse. Curr Opin Genet Dev 11: 476–481. , .
- 2003. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev 17: 141–153. , , , .
- 2004. Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci STKE 2004: E17. , .
- 2002. Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol 4: 165–169. , , , .
- 1996. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122: 1737–1750. , , .
- 2000. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech Dev 90: 103–110. , .
- 1997. FGFR activation in skeletal disorders: too much of a good thing. Trends Genet 13: 178–182. , .
- 2002. FGFs, their receptors, and human limb malformations: clinical and molecular correlations. Am J Med Genet 112: 266–278. , , , , .
- WilkinsonDG, editor. 1992. In situ hybridization. Oxford: Oxford University Press. p 75–83.
- 2002. The progress zone model for specifying positional information. Int J Dev Biol 46: 869–870. .
- 2003. hSef inhibits PC-12 cell differentiation by interfering with Ras-Mitogen-activated protein kinase MAPK signaling. J Biol Chem 278: 50273–50282. , , , , , , , , .
- 2003. A novel IL-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. J Biol Chem 278: 33232–33238. , , , , , .