Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development
Article first published online: 13 MAY 2005
Copyright © 2005 Wiley-Liss, Inc.
Volume 233, Issue 3, pages 853–863, July 2005
How to Cite
Kibschull, M., Magin, T. M., Traub, O. and Winterhager, E. (2005), Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev. Dyn., 233: 853–863. doi: 10.1002/dvdy.20424
- Issue published online: 3 JUN 2005
- Article first published online: 13 MAY 2005
- Manuscript Accepted: 4 MAR 2005
- Manuscript Revised: 1 MAR 2005
- Manuscript Received: 21 DEC 2004
- Deutsche Forschungsgemeinschaft (DFG). Grant Number: Wi 774/10-3
- NIH. Grant Number: 1R01 HD42558-01
- gap junction;
- intercellular communication;
The overlapping expression of gap junctional connexins in tissues has indicated that the channels may compensate for each other. During development, Cx31 and Cx43 are coexpressed in preimplantation embryos, in the spongiotrophoblast of the placenta and in the epidermis. This study shows that Cx31/Cx43 double-deficient mice exhibit the known phenotypes of the single-knockout strains but no combined effects. Thus, Cx43, coexpressed with Cx31 at midgestation in the spongiotrophoblast of the placenta, cannot be responsible for a partial rescue of the lethal Cx31 knockout phenotype, as assumed before (Plum et al. [ 2001] Dev Biol 231:334–337). It follows that both connexins have unique functions in placental development. Despite an altered expression of other epidermal connexin mRNAs, epidermal differentiation and physiology was unaltered by the absence of Cx31 and Cx43. Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43. Developmental Dynamics 233:853–863, 2005. © 2005 Wiley-Liss, Inc.