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Keywords:

  • neurogenesis;
  • proneural;
  • bHLH;
  • NeuroD;
  • neurogenin

Abstract

The role of proneural factors in specifying neuronal progenitors and in promoting neuronal differentiation is conserved from Drosophila to vertebrates. This primer discusses the basic functions of proneural factors in neurogenesis, mechanisms of proneural factor function, and models for how proneural factors generate neuronal subtypes. The primer also features a dialog about current topics and future directions in the field between two experts in neurogenesis: Andrew Jarman, Ph.D., and Jane Johnson, Ph.D. Developmental Dynamics 234:808–813, 2005. © 2005 Wiley-Liss, Inc.