DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye
Article first published online: 21 OCT 2005
Copyright © 2005 Wiley-Liss, Inc.
Special Issue: Campos-Ortega Special Focus
Volume 235, Issue 4, pages 895–907, April 2006
How to Cite
Richard, M., Grawe, F. and Knust, E. (2006), DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Dev. Dyn., 235: 895–907. doi: 10.1002/dvdy.20595
- Issue published online: 10 MAR 2006
- Article first published online: 21 OCT 2005
- Manuscript Accepted: 24 AUG 2005
- Manuscript Received: 26 JUL 2005
- EMBO. Grant Number: ALTF 2002-322
- EU. Grant Number: QLG3-CT-2002-01266
- Deutsche Forschungsgemeinschaft. Grant Number: SFB 590
- Fonds der Chemischen Industrie. Grant Number: Nr. 163 531
The establishment of apicobasal polarity in epithelial cells is a prerequisite for their function. Drosophila photoreceptor cells derive from epithelial cells, and their apical membranes undergo elaborate differentiation during pupal development, forming photosensitive rhabdomeres and associated stalk membranes. Crumbs (Crb), a transmembrane protein involved in the maintenance of epithelial polarity in the embryo, defines the stalk as a subdomain of the apical membrane. Crb organizes a complex composed of several PDZ domain-containing proteins, including DPATJ (formerly known as Discs lost). Taking advantage of a DPATJ mutant line in which only a truncated form of the protein is synthesized, we demonstrate that DPATJ is necessary for the stability of the Crb complex at the stalk membrane and is crucial for stalk membrane development and rhabdomere maintenance during late pupal stages. Moreover, DPATJ protects against light-induced photoreceptor degeneration. Developmental Dynamics 235:895–907, 2006. © 2005 Wiley-Liss, Inc.