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Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1
Article first published online: 21 OCT 2005
DOI: 10.1002/dvdy.20596
Copyright © 2005 Wiley-Liss, Inc.
Additional Information
How to Cite
Chen, H., Mutton, L. N., Prins, G. S. and Bieberich, C. J. (2005), Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1. Dev. Dyn., 234: 961–973. doi: 10.1002/dvdy.20596
Publication History
- Issue published online: 16 NOV 2005
- Article first published online: 21 OCT 2005
- Manuscript Accepted: 26 AUG 2005
- Manuscript Revised: 23 AUG 2005
- Manuscript Received: 6 MAY 2005
Funded by
- National Institutes of Health, NIDDK. Grant Number: DK059152
REFERENCES
- , . 2000. Molecular genetics of prostate cancer. Genes Dev 14: 2410–2434.
- , , , , , , . 2002. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22: 1495–1503.
- , , . 1989. Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. Mol Cell Biol 9: 2254–2257.
- , . 1993. tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7: 1325–1340.
- , , , , , , , , , , , . 1999. Roles for Nkx3.1 in prostate development and cancer. Genes Dev 13: 966–977.
- , , , . 1990. Evidence for positive and negative regulation of the Hox-3.1 gene. Proc Natl Acad Sci U S A 87: 8462–8466.
- , , , . 1996. Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem 271: 31779–31782.
- , , . 1995. A new vector for recombination-based cloning of large DNA fragments from yeast artificial chromosomes. Nucleic Acids Res 23: 4850–4856.
- , , , , . 1996. A long-range regulatory element of Hoxc8 identified by using the pClasper vector. Proc Natl Acad Sci U S A 93: 2426–2430.
- , , , , , , . 1999. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398: 622–627.
- , , , , . 1996. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J Biol Chem 271: 6379–6388.
- , , , , , , . 1997a. A 6-kb promoter fragment mimics in transgenic mice the prostate- specific and androgen-regulated expression of the endogenous prostate- specific antigen gene in humans. Mol Endocrinol 11: 1256–1265.
- , , , , , . 1997b. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate- specific antigen promoter. Mol Endocrinol 11: 148–161.
- , , . 1987. Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement. Prostate 11: 229–242.Direct Link:
- , . 1987. Cell proliferation studies in rat prostate. I. The proliferative role of basal and secretory epithelial cells during normal growth. Prostate 10: 163–178.Direct Link:
- , , , . 1986. Synergism between immunoglobulin enhancers and promoters. Nature 322: 383–385.
- , . 1983. Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Methods Enzymol 101: 411–433.
- , , , , , , , , , , et al. 1994. The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol 8: 230–239.
- , , , . 1987. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51: 975–985.
- , , , , , , , , , , , , . 1997. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics 43: 69–77.
- , . 1989. Drosophila NK-homeobox genes. Proc Natl Acad Sci U S A 86: 7716–7720.
- , , , , , , , , , . 2002. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res 62: 2999–3004.
- , , , , , , . 1996. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 10: 60–69.
- , , . 1998. Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression. Mech Dev 70: 25–34.
- , , , , , . 1999. The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc Natl Acad Sci U S A 96: 9695–9700.
- , , , , , , . 1995. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2–5. Genes Dev 9: 1654–1666.
- , , . 1993. Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5′ promoter region of the gene. Biochemistry 32: 6459–6464.
- , , . 1999. Targeted disruption of the homeobox transcription factor Nkx2–3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126: 2215–2225.
- , , , . 1987. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1: 268–276.
- , , , , . 1991. The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 5: 1921–1930.
- , , , , , , . 1999. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr Biol 9: 911–914.
- , , , . 2000. Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech Dev 95: 163–174.
- , , , , , . 1996. Prostate-specific antigen expression is regulated by an upstream enhancer. J Biol Chem 271: 7043–7051.
- , . 1999. Building the heart piece by piece: modularity of cis-elements regulating Nkx2–5 transcription. Development 126: 4187–4192.
- , , , , , . 1997. Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn 209: 127–138.Direct Link:
- , . 2003. Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev Dyn 228: 767–778.Direct Link:
- , , , . 1993. Targeted recombination-based cloning and manipulation of large DNA segments in yeast. Methods: A Comp Methods Enzymol 5: 161–175.
- , , , , , , . 1998. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125: 2213–2221.
- , , , , . 1999a. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126: 1269–1280.
- , , . 1999b. Expression of the Nkx3.1 homeobox gene during pre and postnatal development. Mech Dev 85: 179–182.
- , , , , , . 2000. Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev Dyn 219: 248–260.
- , . 1999. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 126: 5699–5711.
- , , . 2005. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45: 55–67.
- , , , , , , , , . 2001. A tissue-specific enhancer of the prostate-specific membrane antigen gene, folh1. Genomics 73: 243–254.
- , , , , , , , , . 1997. Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. Prostate 32: 129–139.Direct Link:
- , . 1993. The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev 7: 1277–1289.
- , , . 1997. Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124: 4971–4982.
- , , . 1998. Cloning and analysis of the promoter activity of the human prostatic acid phosphatase gene. Biochem Biophys Res Commun 245: 108–112.
- , , , , . 2000. Expression of human prostatic acid phosphatase gene is regulated by upstream negative and positive elements. Biochim Biophys Acta 1491: 123–132.
- , , , . 1988. Expression of androgen receptors and prostatic steroid-binding protein during development of the rat ventral prostate. J Endocrinol 117: 361–366.

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