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Developmental expression analysis of the mouse and chick orthologues of IRF6: The gene mutated in Van der Woude syndrome
Article first published online: 21 OCT 2005
DOI: 10.1002/dvdy.20598
Copyright © 2005 Wiley-Liss, Inc.
Issue

Developmental Dynamics
Special Issue: Craniofacial Development Special Issue
Volume 235, Issue 5, pages 1441–1447, May 2006
Additional Information
How to Cite
Knight, A. S., Schutte, B. C., Jiang, R. and Dixon, M. J. (2006), Developmental expression analysis of the mouse and chick orthologues of IRF6: The gene mutated in Van der Woude syndrome. Dev. Dyn., 235: 1441–1447. doi: 10.1002/dvdy.20598
Publication History
- Issue published online: 19 APR 2006
- Article first published online: 21 OCT 2005
- Manuscript Accepted: 29 AUG 2005
- Manuscript Received: 15 AUG 2005
Funded by
- National Institutes of Health. Grant Numbers: P50-DE016215, DE015207
- Wellcome Trust. Grant Number: 064732
REFERENCES
- , , . 2002. Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion. Development 129: 4647–4660.
- , , . 1995. Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal mouse embryonic fusion. Int J Dev Biol 39: 345–355.
- , , , , . 1998. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94: 727–737.
- , , , . 2002. Programmed cell death is required for palate shelf fusion and is regulated by retinoic acid. Dev Biol 245: 145–156.
- , , , , . 1998. Immunohistochemical localization of TGF-β3 during palatogenesis in vivo and in vitro. Int J Dev Biol 42: 817–820.
- , , . 1991. Immunolocalisation of epidermal growth factor (EGF), EGF receptor and transforming growth factor alpha (TGFα) during murine palatogenesis in vivo and in vitro. Anat Embryol 184: 83–91.
- . 1988. Palate development. Development 103S: 41–60.
- , , , . 1990. Differential expression of TGF beta isoforms in murine palatogenesis. Development 109: 585–595.
- , . 1992. Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels. Development 116: 1087–1099.
- , , 1951. A series of normal stages in the development of the chick embryo. Dev Dyn 195: 231–272.
- . 1988. Etiology of facial clefts: prospective evaluation of 428 patients. Cleft Palate J 25: 16–20.
- , , , , , , . 1995. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nature Genet 11: 415–421.
- , , , , . 1997. Transforming growth factor-β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane. Dev Dyn 209: 255–260.Direct Link:
- , , , , , , , , , , , , , , , , , , , , , , , , , . 2002. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nature Genet 32: 285–289.
- , , , , , . 2000. Medial edge epithelial cell fate during palatal fusion. Dev Biol 220: 343–357.
- , , , , , , . 1999. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nature Genet 22: 69–73.
- , , . 2000. Characterization of desmosomal component expression during palatogenesis. Int J Dev Biol 44: 317–322.
- . 2002. Gene/environment causes of cleft lip and/or palate. Clin Genet 61: 248–256.Direct Link:
- , , , , , , , , . . 1997. Clinical and epidemiologic studies of cleft lip and palate in the Philippines. Cleft Palate Craniofac J 34: 7–10.
- , , , , . 2002. Mixed clefting type in Rapp-Hodgkin syndrome. Am J Med Genet 108: 281–284.Direct Link:
- , , . 1996. In situ hybridisation analysis of chick embryos in whole mount and tissue sections. Methods Cell Biol 51: 219–235.
- , , , . 1990. Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formation. Dev Biol 141: 456–460.
- , , , , , , , , . 1995. Transforming growth factor-β3 is required for secondary palate fusion. Nature Genet 11: 409–414.
- , . 2003. About face: signals and genes controlling jaw patterning and identity in vertebrates. Bioessays 25: 554–568.Direct Link:
- , . 1980. Development of the secondary palate in the chick embryo: a light and electron microscopic and histochemical study. Invest Cell Pathol 3: 319–328.
- , , , . 1998. TGFβ3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development 125: 95–105.
- , , . 2000. Epithelial-mesenchymal transformation is the mechanism for fusion of the craniofacial primordia involved in morphogenesis of the chicken lip. Dev Biol 228: 337–349.
- , , , , , , . 2000. Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. Nature Genet 25: 427–430.
- , , , . 2001. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19: 623–655
- . 1987. Incidence of cleft lip, cleft palate, and cleft lip and palate among races: a review. Cleft Palate J 24: 216–225.
- , , . 1987. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50: 79–88.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , . 2004. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med 351: 769–780.

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