Vascular anatomy of the developing medaka, Oryzias latipes: A complementary fish model for cardiovascular research on vertebrates
Article first published online: 31 JAN 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 235, Issue 3, pages 734–746, March 2006
How to Cite
Fujita, M., Isogai, S. and Kudo, A. (2006), Vascular anatomy of the developing medaka, Oryzias latipes: A complementary fish model for cardiovascular research on vertebrates. Dev. Dyn., 235: 734–746. doi: 10.1002/dvdy.20696
- Issue published online: 7 FEB 2006
- Article first published online: 31 JAN 2006
- Manuscript Accepted: 22 DEC 2005
- Japan Ministry of Education, Culture, Sports, and Technology of Japan
- vascular anatomy;
- confocal microangiography;
The zebrafish has become a very useful vertebrate model for cardiovascular research, but detailed morphogenetic studies have revealed that it differs from mammals in certain aspects of the primary circulatory system, in particular, the early vitelline circulation. We searched for another teleost species that might serve as a complementary model for the formation of these early primary vessels. Here (and online at http://www.shigen.nig.ac.jp/medaka/atlas/), we present a detailed characterization of the vascular anatomy of the developing medaka embryo from the stage 24 (1 day 20 hr) through stage 30 (3 days 10 hr). Three-dimensional images using confocal microangiography show that the medaka, Oryzias latipes, follows the common embryonic circulatory pattern consisting of ventral aorta, aortic arches, dorsal aorta, transverse vessels, vitelline capillary plexus, and marginal veins. The medaka, thus, may serve as a valuable model system for genetic analysis of the primary vasculature of vertebrates. Developmental Dynamics 235:734–746, 2006. © 2006 Wiley-Liss, Inc.