Patterns & Phenotypes
Inhibins are the major activin ligands expressed during early thymocyte development
Article first published online: 13 FEB 2006
Copyright © 2006 Wiley-Liss, Inc.
Special Issue: Campos-Ortega Special Focus
Volume 235, Issue 4, pages 1124–1132, April 2006
How to Cite
Licona, P., Chimal-Monroy, J. and Soldevila, G. (2006), Inhibins are the major activin ligands expressed during early thymocyte development. Dev. Dyn., 235: 1124–1132. doi: 10.1002/dvdy.20707
- Issue published online: 10 MAR 2006
- Article first published online: 13 FEB 2006
- Manuscript Accepted: 4 JAN 2006
- Consejo Nacional de Ciencia y Tecnología (CONACyT). Grant Numbers: 42797-Q, 42568-Q
- Universidad Nacional Autónoma de México (DGAPA). Grant Number: IN200205
- Alk 4;
- thymocyte development;
Activins are members of the transforming growth factor-beta (TGFβ) superfamily, which regulate cell differentiation processes. Here we report the first quantitative analysis of the expression of Activin/Inhibin ligands, type I and II receptors, as well as Smad proteins in fetal (E14–E16) and adult thymic subpopulations. Our data showed that Alk4, ActRIIA, ActRIIB, and Smads 2, 3, and 4, are expressed in fetal thymus (E14 > E15 > E16) and in thymocytes from adult mice (mostly in the double negative [DN] subpopulation). Ligand expression analysis showed that βA, βB, and α subunits were mainly detected in thymic stromal cells. Interestingly, α subunits were expressed at much higher levels compared to βA and βB subunits, demonstrating for the first time the potential role of Inhibins as important mediators during early T cell development. Our data indicate that Activin/Inhibin signaling could regulate the process of thymus organogenesis and early thymocyte differentiation, as it has been demonstrated for other members of the TGF-β superfamily. Developmental Dynamics 235:1124–1132, 2006. © 2006 Wiley-Liss, Inc.