Holger Kulessa deceased August 2005.
Bmp signaling is required for intestinal growth and morphogenesis
Article first published online: 14 MAR 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 235, Issue 6, pages 1563–1570, June 2006
How to Cite
Batts, L. E., Polk, D. B., Dubois, R. N. and Kulessa, H. (2006), Bmp signaling is required for intestinal growth and morphogenesis. Dev. Dyn., 235: 1563–1570. doi: 10.1002/dvdy.20741
- Issue published online: 4 MAY 2006
- Article first published online: 14 MAR 2006
- Manuscript Accepted: 10 FEB 2006
- Vanderbilt Digestive Disease Research Center. Grant Number: DK58404
- National Colorectal Cancer Research Alliance (NCCRA)
- bone morphogenetic proteins;
- Juvenile Polyposis;
- growth control;
- transgenic mouse;
Intestinal growth, morphogenesis, differentiation, and homeostasis are regulated by reciprocal interactions between the epithelium and the underlying mesenchymal stroma. The identification of BMPR1A mutations in patients with Juvenile Polyposis implicates Bmp signaling as an important mediator of these interactions. To test this hypothesis, we inhibited Bmp signaling in the mouse proximal intestine by transgenic misexpression of the BMP antagonist, noggin, using regulatory elements of the fatty acid binding protein (Fabp1) gene. This leads to abnormal villus morphogenesis, stromal and epithelial hyperplasia, and ectopic crypt formation. The resulting intestinal histopathology resembles that seen in human Juvenile Polyposis. Misexpression of noggin in the large intestine gives a similar abnormal phenotype in this region of the gut. Analysis of gene expression in the transgenic small intestine raises the possibility that Hedgehog and Pdgf signaling play a role in the development of the Juvenile Polyposis-like phenotype. Developmental Dynamics 235:1563–1570, 2006. © 2006 Wiley-Liss, Inc.