Special Issue Reviews–A Peer Reviewed Forum
Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function
Version of Record online: 2 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Special Issue: Mouse Development Special Issue
Volume 235, Issue 9, pages 2315–2329, September 2006
How to Cite
Lewis, S. L. and Tam, P. P.L. (2006), Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function. Dev. Dyn., 235: 2315–2329. doi: 10.1002/dvdy.20846
- Issue online: 9 AUG 2006
- Version of Record online: 2 JUN 2006
- Manuscript Accepted: 12 APR 2006
- definitive endoderm;
- mouse embryo;
- tissue patterning;
- cell fate
The endoderm is one of the primary germ layers but, in comparison to ectoderm and mesoderm, has received less attention. The definitive endoderm forms during gastrulation and replaces the extraembryonic visceral endoderm. It participates in the complex morphogenesis of the gut tube and contributes to the associated visceral organs. This review highlights the role of the definitive endoderm as a source of patterning cues for the morphogenesis of other germ-layer tissues, such as the anterior neurectoderm and the pharyngeal region, and also emphasizes the intricate patterning that the endoderm itself undergoes enabling the acquisition of regionalized cell fates. Developmental Dynamics 235:2315–2329, 2006. © 2006 Wiley-Liss, Inc.