Patterns & Phenotypes
Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis
Version of Record online: 19 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 235, Issue 8, pages 2266–2275, August 2006
How to Cite
Lipscomb, K., Schmitt, C., Sablyak, A., Yoder, J. A. and Nascone-Yoder, N. (2006), Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis. Dev. Dyn., 235: 2266–2275. doi: 10.1002/dvdy.20879
- Issue online: 17 JUL 2006
- Version of Record online: 19 JUN 2006
- Manuscript Accepted: 15 MAY 2006
- Suncoast Cardiovascular Research and Education Foundation
- retinoic acid;
- biliary atresia;
- annular pancreas
The looping events that establish left–right asymmetries in the vertebrate gut tube are poorly understood. Retinoic acid signaling is known to impact left–right development in multiple embryonic contexts, although its role in asymmetric digestive organ morphogenesis is unknown. Here, we show that the genes for retinaldehyde dehydrogenase (RALDH2) and a retinoic acid hydroxylase (CYP26A1) are expressed in complementary patterns in the Xenopus gut during looping. A late-stage chemical genetic assessment reveals that agonists and antagonists of retinoid signaling generate abnormal gut looping topologies, digestive organ heterotaxias, and intestinal malrotations. Accessory organ deformities commonly associated with intestinal malrotation in humans, such as annular pancreas, pancreas divisum, and extrahepatic biliary tree malformations, are also induced by distinct retinoid receptor agonists. Thus, late-stage retinoic acid signaling is likely to play a critical role in asymmetric gut tube morphogenesis and may underlie the etiology of several clinically relevant defects in the digestive system. Developmental Dynamics 235:2266–2275, 2006. © 2006 Wiley-Liss, Inc.