Patterns & Phenotypes
Expression of the protein related to Dan and Cerberus gene—prdc—During eye, pharyngeal arch, somite, and swim bladder development in zebrafish
Article first published online: 18 AUG 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 235, Issue 10, pages 2881–2888, October 2006
How to Cite
Müller, I. I., Knapik, E. W. and Hatzopoulos, A. K. (2006), Expression of the protein related to Dan and Cerberus gene—prdc—During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Dev. Dyn., 235: 2881–2888. doi: 10.1002/dvdy.20925
- Issue published online: 12 SEP 2006
- Article first published online: 18 AUG 2006
- Manuscript Accepted: 12 JUL 2006
- Vanderbilt Development funds
- pharyngeal arches;
- swim bladder
The protein related to Dan and Cerberus, or PRDC, is a secreted glycoprotein, which belongs to the DAN subfamily of bone morphogenetic protein (BMP) antagonists. In zebrafish, prdc is expressed initially around 17 hours postfertilization in the developing eyes and the first two pharyngeal arches. Expression in the eye starts in the outer layers of the optic cup. Later, prdc expression domains are juxtaposed at the edges of the optic cup surrounding the choroid fissure, then gradually becoming restricted to a small site in the ventral marginal zone. Prdc expression in the arch mesenchyme expands stepwise to the remaining posterior arches. Prdc is also detectable in the ventral part of the somites and the mesenchyme of the swim bladder. The relatively late appearance during development is a unique feature of Prdc among BMP antagonists. Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis. Developmental Dynamics 235:2881–2888, 2006. © 2006 Wiley-Liss, Inc.