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Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system

  1. Nandor Nagy1,2,
  2. Katherine C. Brewer1,
  3. Olive Mwizerwa1,
  4. Allan M. Goldstein1,*

Article first published online: 25 AUG 2006

DOI: 10.1002/dvdy.20933

Issue

Developmental Dynamics

Developmental Dynamics

Volume 236, Issue 1, pages 73–83, January 2007

Additional Information

How to Cite

Nagy, N., Brewer, K. C., Mwizerwa, O. and Goldstein, A. M. (2007), Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system. Dev. Dyn., 236: 73–83. doi: 10.1002/dvdy.20933

Author Information

  1. 1

    Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

  2. 2

    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

*Massachusetts General Hospital, Warren 1153, Boston, MA 02114

Publication History

  1. Issue published online: 19 DEC 2006
  2. Article first published online: 25 AUG 2006
  3. Manuscript Accepted: 21 JUL 2006

Funded by

  • NIH. Grant Number: K08HD46655

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REFERENCES

  • Aisa J, Lahoz M, Serrano PJ, Castiella T, Junquera C, Azanza MJ, Vera-Gil A. 1998. Histochemical, immunohistochemical, and electron microscopy study of the caudal portion of the chicken intestinal nerve of Remak. Neurochem Res 23: 845–853.
  • Allan IJ, Newgreen DF. 1980. The origin and differentiation of enteric neurons of the intestine of the fowl embryo. Am J Anat 157: 137–154.
    Direct Link:
  • Anderson RB, Stewart AL, Young HM. 2006. Phenotypes of neural-crest-derived cells in vagal and sacral pathways. Cell Tissue Res 323: 11–25.
  • Browne MJ. 1953. A study of the sacral autonomic nerves in a chick and a human embryo. Anat Rec 116: 189–203.
    Direct Link:
  • Burns AJ. 2005. Migration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract. Int J Dev Biol 49: 143–150.
  • Burns AJ, Le Douarin NM. 1998. The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system. Development 125: 4335–4347.
  • Burns AJ, Le Douarin NM. 2001. Enteric nervous system development: analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras. Anat Rec 262: 16–28.
    Direct Link:
  • Burns AJ, Champeval D, Le Douarin NM. 2000. Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia. Dev Biol 219: 30–43.
  • Burns AJ, Delalande JM, Le Douarin NM. 2002. In ovo transplantation of enteric nervous system precursors from vagal to sacral neural crest results in extensive hindgut colonisation. Development 129: 2785–2796.
  • Catala M, Teillet MA, Le Douarin NM. 1995. Organization and development of the tail bud analyzed with the quail-chick chimaera system. Mech Dev 51: 51–65.
  • Conner PJ, Focke PJ, Noden DM, Epstein ML. 2003. Appearance of neurons and glia with respect to the wavefront during colonization of the avian gut by neural crest cells. Dev Dyn 226: 91–98.
    Direct Link:
  • Doyle AM, Roberts DJ, Goldstein AM. 2004. Enteric nervous system patterning in the avian hindgut. Dev Dyn 229: 708–712.
    Direct Link:
  • Erickson CA, Goins TL. 2000. Sacral neural crest cell migration to the gut is dependent upon the migratory environment and not cell-autonomous migratory properties. Dev Biol 219: 79–97.
  • Goldstein AM, Brewer KC, Doyle AM, Nagy N, Roberts DJ. 2005. BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system. Mech Dev 122: 821–833.
  • Hamburger V, Hamilton HL. 1951. A series of normal stages in the development of the chick embryo. J Morphol 88: 49–92.
    Direct Link:
  • Hearn C, Newgreen D. 2000. Lumbo-sacral neural crest contributes to the avian enteric nervous system independently of vagal neural crest. Dev Dyn 218: 525–530.
    Direct Link:
  • Kapur RP. 2000. Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model. Dev Biol 227: 146–155.
  • Kapur RP, Yost C, Palmiter RD. 1992. A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice. Development 116: 167–175.
  • Kurtz A, Zimmer A, Schnutgen F, Bruning G, Spener F, Muller T. 1994. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development 120: 2637–2649.
  • Le Douarin NM, Teillet MA. 1973. The migration of neural crest cells to the wall of the digestive tract in avian embryo. J Embryol Exp Morphol 30: 31–48.
  • McNagny KM, Pettersson I, Rossi F, Flamme I, Shevchenko A, Mann M, Graf T. 1997. Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors. J Cell Biol 138: 1395–1407.
  • Meijers JH, Tibboel D, van der Kamp AW, van Haperen-Heuts IC, Molenaar JC. 1989. A model for aganglionosis in the chicken embryo. J Pediatr Surg 24: 557–561.
  • Nagy N, Goldstein AM. 2006a. Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system. Dev Biol 293: 203–217.
  • Nagy N, Goldstein AM. 2006b. Intestinal coelomic transplants: a novel method for studying enteric nervous system development. Cell Tissue Res 326: 43–55.
  • Nagy N, Biro E, Takacs A, Polos M, Magyar A, Olah I. 2005. Peripheral blood fibrocytes contribute to the formation of the avian spleen. Dev Dyn 232: 55–66.
    Direct Link:
  • Newgreen DF, Jahnke I, Allan IJ, Gibbins IL. 1980. Differentiation of sympathetic and enteric neurons of the fowl embryo in grafts to the chorio-allantoic membrane. Cell Tissue Res 208: 1–19.
  • Pomeranz HD, Gershon MD. 1990. Colonization of the avian hindgut by cells derived from the sacral neural crest. Dev Biol 137: 378–394.
  • Serbedzija GN, Burgan S, Fraser SE, Bronner-Fraser M. 1991. Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos. Development 111: 857–866.
  • Shepherd IT, Raper JA. 1999. Collapsin-1/semaphorin D is a repellent for chick ganglion of Remak axons. Dev Biol 212: 42–53.
  • Tanaka H, Kinutani M, Agata A, Takashima Y, Obata K. 1990. Pathfinding during spinal tract formation in the chick-quail chimera analysed by species-specific monoclonal antibodies. Development 110: 565–571.
  • Teillet MA. 1978. Evolution of the lumbo-sacral neural crest in the avian embryo: origin and differentiation of the ganglionated nerve of Remak studied in interspecific quail-chick chimerae. Rouxs Arch Dev Biol 184: 251–268.
  • Yntema CL, Hammond WS. 1954. The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo. J Comp Neurol 101: 515–541.
    Direct Link:
  • Yntema CL, Hammond WS. 1955. Experiments on the origin and development of the sacral autonomic nerves in the chick embryo. J Exp Zool 129: 375–413.
    Direct Link:
  • Young HM, Newgreen D. 2001. Enteric neural crest-derived cells: origin, identification, migration, and differentiation. Anat Rec 262: 1–15.
    Direct Link:
  • Young HM, Hearn CJ, Ciampoli D, Southwell BR, Brunet JF, Newgreen DF. 1998. A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture. Dev Biol 202: 67–84.
  • Young HM, Bergner AJ, Muller T. 2003. Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine. J Comp Neurol 456: 1–11.
    Direct Link:
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