Special Focus Research Article
Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system
Version of Record online: 30 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 236, Issue 1, pages 93–105, January 2007
How to Cite
Hendershot, T. J., Liu, H., Sarkar, A. A., Giovannucci, D. R., Clouthier, D. E., Abe, M. and Howard, M. J. (2007), Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system. Dev. Dyn., 236: 93–105. doi: 10.1002/dvdy.20989
- Issue online: 19 DEC 2006
- Version of Record online: 30 OCT 2006
- Manuscript Accepted: 19 SEP 2006
- National Institutes of Health. Grant Numbers: NIDDK067064, NS040644, DE14181, DE14765
- American Heart Association. Grant Number: 0555176B
- 2002. Proneural genes and the specification of neural cell fates. Nature Rev Neurosci 3: 517–530. , , .
- 1996. Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal markers and MASH-1-dependence. Development 122: 309–320. , , , , , ,
- 2000. Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome. Hum Mol Genet 9: 1907–1917. , , , , , , , .
- 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267: 135–152. , , , , .
- 2002. Phox2 genes-from patterning to connectivity. Curr Opin Gene Dev 12: 435–440 , .
- 2004. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum Mol Genet 13: 2289–2301. , , , , , , .
- 2003. Patterning cell types in the dorsal spinal cord: what the mouse mutants say. Nat Rev Neurosci 4: 289–297. , and
- 1994. Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. J Neurosci 14: 6571–6584. , , , , , .
- 2005. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci 8: 1510–1515. , , , , , , , .
- 2005. Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation. EMBO J 24: 4392–4403. , , , .
- 1995. Expression of the novel basic-helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse neurogenesis. Dev Biol 170: 664–678. , , , .
- 1998 Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8: 1323–1326. , , , , .
- 2005. Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mech Dev 122: 659–669. , , , , .
- 2005. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol 280: 396–406. , , , , , .
- 2003. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: A mechanism for tissue-specific transcriptional regulation. Mol Cell 12: 1225–1237 , , , , , , , , .
- 2006. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci 103: 1319–1324. , , , , , , , , , , , , , , , , , ,
- 2004. Developmental biology of the enteric nervous system: pathogenesis of Hirschsprung's disease and other congenital dysmotilities. Semin Pediatr Surg 13: 224–235. , .
- 2005. Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development 132: 5461–5469. , , , , .
- 2002. Specification of catecholaminergic and serotonergic neurons. Nat Rev Neurosci 3: 531–541. , .
- 1995. Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons. Development 121: 887–901. , , , , , .
- 1993. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75: 463–476. , , , , , .
- 1998. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci USA. 95: 5161–5165. , , , , , , , , .
- 2005. Mechanisms and perspectives on differentiation of autonomic neurons. Dev Biol 277: 271–286. .
- 1985. The influence of neural tube-derived factors on differentiation of neural crest cells in vitro. 1. Histochemical study on the appearance of adrenergic cells. J Neurosci 5: 3302–3309. , .
- 1999. Expression of HAND gene products may be sufficient for the differentiation of neural crest-derived cells into catecholaminergic neurons in avians. Dev Biol 215: 62–77. , , .
- 2000. Evidence for an important role of HAND genes in the network of transcriptional regulators controlling sympathetic neuron development. Development 127: 4073–4081. , , , , .
- 2000. Fate of mammalian cardiac neural crest. Development 127: 1607–1616. , , , , .
- 2003. Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. Hum Mol Genet 12: 937–945. , .
- 2000. Pax3 is required for enteric ganglia formation and function with Sox10 to modulate expression of c-ret. J Clin Invest 106: 963–971. , , , , , .
- 2001. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat Neurosci 4(Suppl): 1183–1191. , .
- 2005. BMP4 supports noradrenergic differentiation by a PKA-dependent mechanism. Dev Biol 286: 521–536. , , .
- 1999. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells. Neuron 22: 693–705. , , , .
- 2005. The basic helix-loop-helix factor Han2 regulates autonomic nervous system development. Dev Dyn 234: 613–621. , , , , ,
- 1997. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron 18: 411–423. , , , , .
- 2002. Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage. Development 129: 5707–5717. , .
- 2002. Enteric nervous system: Development and developmental disturbances-Part 1. Pediatr Dev Pathol 5: 224–247. , .
- 1999. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399: 366–370. , , , , .
- 1998. SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Nat Genet 18: 171–173. , , , , , , , , , , , , , , , , ,
- 1993. Neural crest-derived cells isolated from the gut by immunoselection develop neuronal and glial phenotypes when cultured on laminin. Dev Biol 156: 341–361. , , , , .
- 2003. The interaction between dHAND and Arix at the dopamine-β-hydroxylase promoter region is independent of direct dHAND binding to DNA. J Biol Chem 278: 49652–49660. , , .
- 2004. Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development 131: 4413–4423. , , , , .
- 2006. Perspectives on integration of cell extrinsic and cell intrinsic pathways of signaling required for differentiation of noradrenergic sympathetic ganglion neurons. Auton Neurosci 126-127: 225–231. , .
- 2005. Control of gastrointestinal motility by the “Gut Brain”-The enteric nervous system. J Ped Gastro Nutr 41: S4–S6. .
- 1998. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse models. Nat Genet 18: 60–64. , , .
- 2006. Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol 291: 232–249. , , , , , , , .
- 1999. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons. Development 126: 4087–4094. , , , , , .
- 1997. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor dHAND. Nat Genet 16: 154–160. , , , , , .
- 2002. Transcripts encoding HAND genes are differentially expressed and regulated by BMP4 and GDNF in developing avian gut. Gene Express 10: 291–305. , .
- 2003. HAND2 synergistically enhances transcription of dopamine-□-hydroxylase in the presence of Phox2a. Dev Biol 262: 183–193. , , , .
- 2000. The basic helix-lop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest 105: 261–270. , , .
- 2003. Acquisition of neuronal and glial markers by neural crest-derived cell in the mouse intestine. J Comp. Neurol 456: 1–11. , , .