N. Klüver and Dr. Pfennig contributed equally to this work.
Patterns & Phenotypes
Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka
Version of Record online: 30 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 236, Issue 1, pages 271–281, January 2007
How to Cite
Klüver, N., Pfennig, F., Pala, I., Storch, K., Schlieder, M., Froschauer, A., Gutzeit, H. O. and Schartl, M. (2007), Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev. Dyn., 236: 271–281. doi: 10.1002/dvdy.20997
- Issue online: 19 DEC 2006
- Version of Record online: 30 OCT 2006
- Manuscript Accepted: 28 SEP 2006
- Deutsche Forschungsgemeinschaft. Grant Number: Gu 208/12-3
- anti-Müllerian hormone;
- Amh type II receptor;
- gonad development;
- sex determination;
- sex differentiation
In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes. Developmental Dynamics 236:271–281, 2007. © 2006 Wiley-Liss, Inc.