Patterns & Phenotypes
Regionalized expression of ADAM13 during chicken embryonic development
Article first published online: 23 JAN 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 3, pages 862–870, March 2007
How to Cite
Lin, J., Redies, C. and Luo, J. (2007), Regionalized expression of ADAM13 during chicken embryonic development. Dev. Dyn., 236: 862–870. doi: 10.1002/dvdy.21071
- Issue published online: 22 FEB 2007
- Article first published online: 23 JAN 2007
- Manuscript Accepted: 20 DEC 2006
- gene expression pattern;
- neural crest;
- dorsal aorta;
- branchial arch;
ADAMs are a family of membrane proteins possessing a disintegrin domain and a metalloprotease domain, which have functions in cell–cell adhesion, cell–matrix adhesion, and protein shedding, respectively. ADAMs are involved in morphogenesis and tissue formation during embryonic development. In the present study, chicken ADAM13 was cloned and identified, and its expression was investigated by semiquantitative reverse transcriptase-polymerase chain reaction and in situ hybridization during chicken embryonic development. Our results show that ADAM13 expression is temporally and spatially regulated in chicken embryos. At early developmental stages, ADAM13 is expressed in the head mesenchyme, which later develops into the craniofacial skeleton, in the branchial arches, and in the meninges surrounding the brain. Furthermore, ADAM13 mRNA was also detected in several tissues and organs, such as the somites and their derived muscles, the meninges surrounding the spinal cord, the dorsal aorta, the developing kidney, and several digestive organs. Developmental Dynamics 236:862–870, 2007. © 2007 Wiley-Liss, Inc.