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Tob genes in development and homeostasis
Article first published online: 15 FEB 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 4, pages 913–921, April 2007
How to Cite
Jia, S. and Meng, A. (2007), Tob genes in development and homeostasis. Dev. Dyn., 236: 913–921. doi: 10.1002/dvdy.21092
- Issue published online: 15 MAR 2007
- Article first published online: 15 FEB 2007
- Manuscript Accepted: 16 JAN 2007
- National Basic Research Program of China. Grant Number: 2005CB522502
- Grand Research Program of China. Grant Number: 2006CB943401
- National Natural Science Foundation of China. Grant Number: 30570197
Members of the Btg/Tob protein family share a conserved N-terminal region that confers the activity to inhibit cell proliferation. Tob1 and Tob2 proteins, which constitute a Tob subfamily, have a longer C-terminal region than BTG proteins. Apparently, genomes of invertebrates and teleost species contain only a single Tob locus, whereas genomes of mammalian, avian, and amphibian species contain two Tob loci (Tob1 and Tob2). Tob genes are expressed in oocytes, sperm, early embryos, and various adult tissues, depending on the species. Recent reports indicate that Tob proteins play important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, and learning and memory. Accumulating evidence supports the hypothesis that Tob proteins act primarily as transcriptional repressors in several signaling pathways. Developmental Dynamics 236:913–921, 2007. © 2007 Wiley-Liss, Inc.