Patterns & Phenotypes
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development
Article first published online: 15 MAR 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 4, pages 1134–1143, April 2007
How to Cite
Ohuchi, H., Hayashibaral, Y., Matsuda, H., Onoi, M., Mitsumori, M., Tanaka, M., Aoki, J., Arai, H. and Noji, S. (2007), Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. Dev. Dyn., 236: 1134–1143. doi: 10.1002/dvdy.21119
- Issue published online: 15 MAR 2007
- Article first published online: 15 MAR 2007
- Manuscript Accepted: 13 FEB 2007
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). Grant Numbers: 18022029, A01 0001
- Knowledge Cluster Initiative (MEXT)
- PRESTO (Japan Science and Technology Corporation)
- nucleotide pyrophosphatase-phosphodiesterase 2;
- brain development;
Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that generates bioactive phospholipids that act on G protein–coupled receptors. Here we show the expression patterns of the ATX gene in mouse and chicken embryos. ATX has a dynamic spatial and temporal expression pattern in both species and the expression domains during neural development are quite distinct from each other. Murine ATX (mATX) is expressed immediately rostral to the midbrain-hindbrain boundary, whereas chicken ATX (cATX) is expressed in the diencephalon and later in the parencephalon-synencephalon boundary. In the neural tube, cATX is expressed in the alar plate in contrast to mATX in the floor plate. ATX is also expressed in the hindbrain and various organ primordia such as face anlagen and skin appendages of the mouse and chicken. These results suggest conserved and non-conserved roles for ATX during neural development and organogenesis in these species. Developmental Dynamics 236:1134–1143, 2007. © 2007 Wiley-Liss, Inc.