Special Issue Reviews–A Peer Reviewed Forum
Coupling cellular oscillators: A mechanism that maintains synchrony against developmental noise in the segmentation clock
Article first published online: 9 APR 2007
Copyright © 2007 Wiley-Liss, Inc.
Special Issue: Special Focus on Segmentation
Volume 236, Issue 6, pages 1416–1421, June 2007
How to Cite
Ishimatsu, K., Horikawa, K. and Takeda, H. (2007), Coupling cellular oscillators: A mechanism that maintains synchrony against developmental noise in the segmentation clock. Dev. Dyn., 236: 1416–1421. doi: 10.1002/dvdy.21139
- Issue published online: 16 MAY 2007
- Article first published online: 9 APR 2007
- Manuscript Accepted: 1 MAR 2007
- coupled oscillator;
- segmentation clock;
A unique feature of vertebrate segmentation is its strict periodicity, which is governed by the segmentation clock consisting of numerous cellular oscillators. These cellular oscillators, driven by a negative-feedback loop of Hairy transcription factor, are linked through Notch-dependent intercellular coupling and display the synchronous expression of clock genes. Combining our transplantation experiments in zebrafish with mathematical simulations, we review how the cellular oscillators maintain synchrony and form a robust system that is resistant to the effects of developmental noise such as stochastic gene expression and active cell proliferation. The accumulated evidence indicates that the segmentation clock behaves as a “coupled oscillators,” a mechanism that also underlies the synchronous flashing seen in fireflies. Developmental Dynamics 236:1416–1421, 2007. © 2007 Wiley-Liss, Inc.