Patterns & Phenotypes
Expression of Notch pathway genes in mammalian epidermis and modulation by β-Catenin
Article first published online: 1 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
Special Issue: Special Focus on Segmentation
Volume 236, Issue 6, pages 1595–1601, June 2007
How to Cite
Ambler, C. A. and Watt, F. M. (2007), Expression of Notch pathway genes in mammalian epidermis and modulation by β-Catenin. Dev. Dyn., 236: 1595–1601. doi: 10.1002/dvdy.21151
- Issue published online: 16 MAY 2007
- Article first published online: 1 MAY 2007
- Manuscript Accepted: 9 MAR 2007
- Cancer Research UK
- EuroStemCell FP6 Programme
- NIH. Grant Number: F32-AR049651
The Notch pathway is required for hair follicle maintenance and is activated through β-catenin induced transcription of the Notch ligand Jagged1. We show that hair follicles in the resting phase express low levels of Jagged1 and Hes1, and other Notch target genes are undetectable. In growing (anagen) follicles, Jagged1 and Hes1 expression increases, Hes5 and HeyL are expressed in distinct cell layers, and Hey2 is expressed in the dermal papilla. When β-catenin is activated by means of an inducible transgene, Jagged1, Hes1, Hes5, HeyL, and Hey2 are up-regulated, the sites of expression being the same in β-catenin induced ectopic follicles as in anagen follicles. β-Catenin also induces Hey1 in dermal papilla cells. β-Catenin–induced up-regulation of Jagged1 precedes induction of other Notch target genes. The different sites of expression of Hes and Hey genes suggest input from additional signaling pathways. Developmental Dynamics 236:1595–1601, 2007. © 2007 Wiley-Liss, Inc.