Drs. Kriebel and Müller contributed equally to this work.
Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos
Article first published online: 3 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
Special Issue: Special Focus on Segmentation
Volume 236, Issue 6, pages 1526–1534, June 2007
How to Cite
Kriebel, M., Müller, F. and Hollemann, T. (2007), Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos. Dev. Dyn., 236: 1526–1534. doi: 10.1002/dvdy.21170
- Issue published online: 16 MAY 2007
- Article first published online: 3 MAY 2007
- Manuscript Accepted: 7 MAR 2007
- Deutsche Forschungsgemeinschaft. Grant Number: HO1879/4-1
- BMBF. Grant Number: SI/03
- neural development;
- eyes absent;
- Xenopus laevis
The transcriptional coactivater and tyrosine phosphatase eyes absent (eya) is vital for eye development in Drosophila. We identified a vertebrate member of the Eya family, Xeya3, which is expressed in the anterior neural plate, including the eye field. Overexpression of wild-type Xeya3 or of a phosphatase-negative version of Xeya3 creates massive enlargements of brain and retinal tissues, mainly caused by overproliferation of neural precursor cells. On the other hand, suppression of Xeya3 function induces local apoptosis within the sensorial layer of the anterior neuroectoderm. Thus, Xeya3 is key factor for the formation and size control of brain and eyes in vertebrates. Developmental Dynamics 236:1526–1534, 2007. © 2007 Wiley-Liss, Inc.