A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development

Authors

  • Brian S. Snarr,

    1. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, Charleston, South Carolina
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  • Elaine E. Wirrig,

    1. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, Charleston, South Carolina
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  • Aimee L. Phelps,

    1. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, Charleston, South Carolina
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  • Thomas C. Trusk,

    1. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, Charleston, South Carolina
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  • Andy Wessels

    Corresponding author
    1. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, Charleston, South Carolina
    2. Department of Pediatrics, Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina
    3. Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina
    • Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue, Basic Science Building, Room 648B, P.O. Box 250508, Charleston, SC 29425
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Abstract

A composite of images taken from figures in Snarr et al. Upper Left: Histological demonstration of endocardial (lacZ) and non-endocardial derived cells in the atrioventricular (AV) mesenchyme of a Tie2-Cre/R26R mouse heart at ED11.5. Upper Right: Superior view of an AMIRA 3D reconstruction of an ED11.5, Tie2-Cre/R26R heart. Colors distinguish the different mesenchymal components in the AV region. Center: Left lateral view of the ED11.5 reconstruction illustrating the relationship of the different mesenchymal components to the primary atrial septum (PAS). Bottom Left: Histological demonstration of endocardial (lacZ) and non-endocardial derived cells in the AV mesenchyme at ED13. Bottom Right: A 3D reconstruction demonstrating the spatial relationship of the different AV mesenchymal tissues at ED 13. See Snarr et al., Developmental Dynamics 236:1287–1294.

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