Special Issue Reviews–A Peer Reviewed Forum
Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: Role of the Eph receptors
Article first published online: 7 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
Special Issue: Special Focus on Stem Cells
Volume 236, Issue 12, pages 3283–3296, December 2007
How to Cite
Hess, A. R., Margaryan, N. V., Seftor, E. A. and Hendrix, M. J.C. (2007), Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: Role of the Eph receptors. Dev. Dyn., 236: 3283–3296. doi: 10.1002/dvdy.21190
- Issue published online: 14 NOV 2007
- Article first published online: 7 JUN 2007
- Manuscript Accepted: 16 APR 2007
- Melanoma Research Foundation
- US National Institutes of Health (NIH). Grant Numbers: CA59702, CA80318
- vasculogenic mimicry;
During embryogenesis, the primordial microcirculation is formed through a process known as vasculogenesis. The term “vasculogenic mimicry” has been used to describe the manner in which highly aggressive, but not poorly aggressive melanoma tumor cells express endothelial and epithelial markers and form vasculogenic-like networks similar to embryonic vasculogenesis. Vasculogenic mimicry is one example of the remarkable plasticity demonstrated by aggressive melanoma cells and suggests that these cells have acquired an embryonic-like phenotype. Since the initial discovery of tumor cell vasculogenic mimicry by our laboratory, we have been focusing on understanding the molecular mechanisms that regulate this process. This review will highlight recent findings identifying key signal transduction events that regulate melanoma vasculogenic mimicry and their similarity to the signal transduction events responsible for promoting embryonic vasculogenesis and angiogenesis. Specifically, this review will focus on the role of the Eph receptors and ligands in embryonic vasculogenesis, angiogenesis, and vasculogenic mimicry. Developmental Dynamics 236:3283–3296, 2007. © 2007 Wiley-Liss, Inc.