The JAK/STAT pathway regulates proximo-distal patterning in Drosophila
Article first published online: 11 JUL 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 10, pages 2721–2730, October 2007
How to Cite
Ayala-Camargo, A., Ekas, L. A., Flaherty, M. S., Baeg, G.-H. and Bach, E. A. (2007), The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Dev. Dyn., 236: 2721–2730. doi: 10.1002/dvdy.21230
- Issue published online: 18 SEP 2007
- Article first published online: 11 JUL 2007
- Manuscript Accepted: 14 MAY 2007
- Breast Cancer Alliance, Inc.
- Pharmacological Sciences Training Grant (N.I.H.). Grant Number: GM066704-01
- proximo-distal axis;
JAK/STAT signaling is thought to control growth and proliferation. However, here we show a novel role for this pathway in the patterning of Drosophila appendages. Loss of Stat92E function results mainly in ventralizations and multiplications of the proximo-distal axis in leg and antenna, primarily through the ectopic misexpression of wingless. We also show that the pathway ligand Unpaired is expressed in two domains in leg and antenna that abuts those of wingless and decapentaplegic. We report that JAK/STAT signaling represses both wingless and decapentaplegic, restricting them to their respective domains in leg and antenna. In a reciprocal manner, we show that wingless and decapentaplegic restrict unpaired to its two domains. Thus, a main function of the JAK/STAT pathway in leg and antennal development is to promote the formation of a single proximo-distal axis per disc by constraining the intersection of wingless and decapentaplegic to the center of the disc. Developmental Dynamics 236:2721–2730, 2007. © 2007 Wiley-Liss, Inc.