Patterns & Phenotypes
Cadherin expression in the developing chicken cochlea
Version of Record online: 25 JUL 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 8, pages 2331–2337, August 2007
How to Cite
Luo, J., Wang, H., Lin, J. and Redies, C. (2007), Cadherin expression in the developing chicken cochlea. Dev. Dyn., 236: 2331–2337. doi: 10.1002/dvdy.21248
- Issue online: 25 JUL 2007
- Version of Record online: 25 JUL 2007
- Manuscript Accepted: 31 MAY 2007
- gene expression pattern;
- chicken development
In this study, we demonstrate that eight classic cadherins are differentially expressed in distinct anatomical regions of the cochlea during late stages of chicken embryonic development. Cadherin-6B is expressed in hair cells and spindle-shaped cells, while cadherin-8 mRNA is found only in supporting cells. Cadherin-11 is widely expressed not only in mesenchymal cell around the cochlea, but also in supporting cells and homogene cells. N-cadherin is found in the sensory epithelium, the neurons of the acoustic ganglion and on their neurites that target the hair cells. Three closely related cadherins (cadherin-7, cadherin-19, and cadherin-20) are expressed in a partially complementary manner in spindle-shaped cells and acoustic ganglion cells. R-cadherin is observed in homogene cells, acoustic ganglion cells, and their projections to hair cells. The expression of classic cadherins in the developing cochlea suggests a role for cadherins in the development of the cochlea. Developmental Dynamics 236:2331–2337, 2007. © 2007 Wiley-Liss, Inc.