Drs. Wu and Li contributed equally to this work.
Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development
Version of Record online: 11 SEP 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 10, pages 2767–2778, October 2007
How to Cite
Wu, X., Li, S., Chrostek-Grashoff, A., Czuchra, A., Meyer, H., Yurchenco, P. D. and Brakebusch, C. (2007), Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development. Dev. Dyn., 236: 2767–2778. doi: 10.1002/dvdy.21309
- Issue online: 18 SEP 2007
- Version of Record online: 11 SEP 2007
- Manuscript Accepted: 16 JUL 2007
- German Research Council (DFG)
- Max Planck Society
- National Institutes of Health. Grant Number: R01 DK36425
- 2000. Altered synthesis of laminin 1 and absence of basement membrane component deposition in β1 integrin-deficient embryoid bodies. J Cell Sci 113: 259–268. , , , , .
- 2006. The Rho GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099–1107. , , , , , , , , , , , .
- 2000. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol 10: 758–765. , , , , , , , , , , , , , , .
- 2006. Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Bio 26: 6957–6970. , , , , , , , , .
- 2005. Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell 16: 4473–4484. , , , , , , , .
- 2005. contribution of cell contact pattern, specific PKC isoforms and gap junctional communication in tight junction assembly in the mouse early embryo. Dev Biol 288: 234–247. , , , , , .
- 2004. Cdc42—the centre of polarity. J Cell Sci 15: 1291–1300. .
- 2002. Rho GTPases in cell biology. Nature 420: 629–635. , .
- 2003. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421: 753–756. , .
- 2002. Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev 16: 784–789. , , , , , , , .
- 2002. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol 12: 221–225. , , .
- 2005. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247–269. , .
- 1995. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 15: 141–151. , .
- 1999. Involvement of Cdc42 small G protein in cell–cell adhesion, migration and morphology of MDCK cells. Oncogene 18: 3996–4006. , , , , .
- 1999. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat Cell Biol 1: 8–13. , , .
- 1997. Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells. Mol Cell Biol 17: 3817–3822. , .
- 2002. Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. J Cell Biol 157: 1279–1290. , , , , , , .
- 2003. The role of laminin in embryonic cell polarization and tissue organization. Dev Cell 4: 613–624. , , , , .
- 2000. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2: 540–547. , , , , , .
- 2005. Role that phosphorylation of GSK3 plays in insulin and Wnt signaling defined by knockin analysis. EMBO J 24: 1571–1583. , , , , , , .
- 2006. Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells. Mol Biol Cell 17: 1922–1932. , , .
- 2005. The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J Cell Biol 170: 1029–1037. , , , , .
- 2000. Regulation of programmed cell death by basement membranes in embryonic development. J Cell Biol 150: 1215–1221. , .
- 2001. cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network. EMBO J 20: 2171–2179. , , , .
- 2003. Adaptation of core mechanisms to generate cell polarity. Nature 422: 766–774. .
- 1995. Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Development 121: 755–765. , .
- 2000. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation. Curr Biol 10: 697–707. , , .
- 1999. Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol 144: 151–160. , , , , , , .
- 1998. Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17: 3427–3433. , , , , , , , , , , .
- 2001. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol 152: 1183–1196. , , , , , , , , , .
- 2002. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci 115: 3565–3573. , , , , , .
- 1997. Regulation of cell–cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol 139: 1047–1059. , , , , .
- 2006. Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell 17: 2377–2390. , , , , .
- 2004. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem 279: 44785–44794. , , , , , , .
- 2006a. Cdc42 controls progenitor cell differentiation and β-catenin turnover in skin. Genes Dev 20: 571–585. , , , , , , , , .
- 2006b. Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin. Matrix Biol 25: 466–474. , , .
- 2001. Par-6 regulates aPKC activity in a novel way an mediates cell–cell contact induced formation of the epithelial juncitonal complex. Genes Cells 6: 721–731. , , , , , , , , , , .
- 2000. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol 149: 775–782. , , , , , .