Caenorhabditis elegans germ line: A model for stem cell biology


  • E. Jane Albert Hubbard

    Corresponding author
    1. New York University School of Medicine, Developmental Genetics, Skirball Institute for Biomolecular Medicine, Department of Pathology, Helen and Martin Kimmel Center for Stem Cell Biology, New York, New York
    • The Helen L. and Martin S. Kimmel Center for Biology and Medicine, at the Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016
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Like many stem cell systems, the Caenorhabditis elegans germ line contains a self-renewing germ cell population that is maintained by a niche. Although the exact cellular mechanism for self-renewal is not yet known, three recent studies shed considerable light on the cell cycle behavior of germ cells, including a support for significant and plastic renewal potential. This review brings together the results of the three recent cell-based studies, places them in the context of previous work, and discusses future perspectives for the field. Developmental Dynamics 236:3343–3357, 2007. © 2007 Wiley-Liss, Inc.