Nitric oxide in the crustacean brain: Regulation of neurogenesis and morphogenesis in the developing olfactory pathway
Article first published online: 18 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 236, Issue 11, pages 3047–3060, November 2007
How to Cite
Benton, J.L., Sandeman, D.C. and Beltz, B.S. (2007), Nitric oxide in the crustacean brain: Regulation of neurogenesis and morphogenesis in the developing olfactory pathway. Dev. Dyn., 236: 3047–3060. doi: 10.1002/dvdy.21340
- Issue published online: 18 OCT 2007
- Article first published online: 18 OCT 2007
- Manuscript Accepted: 27 AUG 2007
- NIH. Grant Number: 1R01 MH67157
- NSF. Grant Number: IBN 0344448
- The Maren Foundation
- Mount Desert Island Biological Laboratory
- nitric oxide;
- adult neurogenesis
Nitric oxide (NO) plays major roles during development and in adult organisms. We examined the temporal and spatial patterns of nitric oxide synthase (NOS) appearance in the embryonic lobster brain to localize sources of NO activity; potential NO targets were identified by defining the distribution of NO-induced cGMP. Staining patterns are compared with NOS and cyclic 3,5 guanosine monophosphate (cGMP) distribution in adult lobster brains. Manipulation of NO levels influences olfactory glomerular formation and stabilization, as well as levels of neurogenesis among the olfactory projection neurons. In the first 2 days following ablation of the lateral antennular flagella in juvenile lobsters, a wave of increased NOS immunoreactivity and a reduction in neurogenesis occur. These studies implicate nitric oxide as a developmental architect and also support a role for this molecule in the neural response to injury in the olfactory pathway. Developmental Dynamics 236:3047–3060, 2007. © 2007 Wiley-Liss, Inc.