Special Issue Reviews–A Peer Reviewed Forum
Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
Article first published online: 31 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
Special Issue: Special Focus on Stem Cells
Volume 236, Issue 12, pages 3218–3227, December 2007
How to Cite
Spence, J. R. and Wells, J. M. (2007), Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev. Dyn., 236: 3218–3227. doi: 10.1002/dvdy.21366
- Issue published online: 14 NOV 2007
- Article first published online: 31 OCT 2007
- Manuscript Accepted: 27 SEP 2007
- Juvenile Diabetes Research Foundation
- NIH. Grant Numbers: GM072915, T32 HD07463
- endoderm organ ogenesis;
Diseases that affect endodermally derived organs such as the lungs, liver, and pancreas include cystic fibrosis, chronic hepatitis, and diabetes, respectively. Despite the prevalence of these diseases, cures remain elusive. While several promising transplantation-based therapies exist for some diseases such as Type 1 diabetes, they are currently limited by the availability of donor-derived tissues. Embryonic stem cells are a promising and renewable source of tissue for transplantation; however, directing their differentiation into specific, adult cell lineages remains a significant challenge. In this review, we will focus on one endodermally derived organ, the pancreas, and discuss how studies of embryonic pancreas development have been used as the basis for the directed, step-wise differentiation of mouse and human embryonic stem cells into pancreatic endocrine cells that are capable of rescuing Type 1 diabetes in animal models. Developmental Dynamics 236:3218–3227, 2007. © 2007 Wiley-Liss, Inc.