Drs. Pietri and Easley-Neal contributed equally to this study.
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Patterns & Phenotypes
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Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish
Article first published online: 19 DEC 2007
DOI: 10.1002/dvdy.21397
Copyright © 2007 Wiley-Liss, Inc.
Additional Information
How to Cite
Pietri, T., Easley-Neal, C., Wilson, C. and Washbourne, P. (2008), Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish. Dev. Dyn., 237: 233–246. doi: 10.1002/dvdy.21397
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Drs. Pietri and Easley-Neal contributed equally to this study.
Publication History
- Issue published online: 19 DEC 2007
- Article first published online: 19 DEC 2007
- Manuscript Accepted: 2 NOV 2007
Funded by
- Whitehall Foundation
- Autism Speaks
- NIH
Keywords:
- Cadm;
- SynCAM;
- IGSF4;
- Necl;
- zebrafish;
- central nervous system
Abstract
The Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development. Developmental Dynamics 237:233–246, 2008. © 2007 Wiley-Liss, Inc.