Patterns & Phenotypes
Slits and robos in the developing chicken inner ear
Article first published online: 21 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 2, pages 476–484, February 2008
How to Cite
Battisti, A. C. and Fekete, D. M. (2008), Slits and robos in the developing chicken inner ear. Dev. Dyn., 237: 476–484. doi: 10.1002/dvdy.21429
- Issue published online: 21 JAN 2008
- Article first published online: 21 JAN 2008
- Manuscript Accepted: 4 DEC 2007
- NIH. Grant Number: DC002756
- axon guidance;
- chicken embryo;
- inner ear;
Mechanosensory hair cells in the chick inner ear synapse onto afferent neurons of the statoacoustic ganglion (SAG). During development, these neurons extend a central process to the brain and a peripheral process into one of eight sensory organs. A combination of cues, including chemoattractants and chemorepellents, direct otic axons to their peripheral targets. As a first step in evaluating the role of known axon guidance molecules, Slits and Robos, we examined expression of their transcripts in the chick inner ear from embryonic day 2–11 (Hamburger and Hamilton stages 14–37). Robo2 and slit2 are in migrating neuroblasts and the SAG, while both slits and robos are in the otic epithelium. We speculate that this family of signaling molecules may be involved in repulsion, first of otic neuroblasts and then of otic axons. Later our expression data revealed a potentially novel role for these molecules in maintaining sensory/nonsensory boundaries. Developmental Dynamics 237:476–484, 2008. © 2008 Wiley-Liss, Inc.