Special Issue Research Article
You have full text access to this OnlineOpen article
Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit
Article first published online: 13 APR 2008
DOI: 10.1002/dvdy.21535
Copyright © 2008 Wiley-Liss, Inc.
Issue

Developmental Dynamics
Special Issue: Special Focus on Left-Right Asymmetry
Volume 237, Issue 12, pages 3516–3527, December 2008
Additional Information
How to Cite
Feistel, K. and Blum, M. (2008), Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit. Dev. Dyn., 237: 3516–3527. doi: 10.1002/dvdy.21535
Publication History
- Issue published online: 20 NOV 2008
- Article first published online: 13 APR 2008
- Manuscript Accepted: 27 FEB 2008
Funded by
- Boehringer Ingelheim Fonds
- DFG. Grant Number: BL 285/7
REFERENCES
- , , . 2003. Genetics of human laterality disorders: insights from vertebrate model systems. Annu Rev Genomics Hum Genet 4: 1–32.
- , , , , , , , , , . 2006. Ciliation and gene expression distinguish node and posterior notochord in the mammalian embryo. Differentiation 75: 133–146.
- , , . 1999. FGF8 functions in the specification of the right body side of the chick. Curr Biol 9: 277–280.
- , . 2002. The evolution of left-right asymmetry in chordates. Bioessays 24: 1004–1011.
- , , . 2002. Nodal activity in the node governs left-right asymmetry. Genes Dev 16: 2339–2344.
- , , , . 1995. Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality. N Engl J Med 332: 1323–1329.
- , . 2004. Gap junction channel gating. Biochim Biophys Acta 1662: 42–60.
- , , , . 2000. Mechanisms of left-right determination in vertebrates. Cell 101: 9–21.
- , , . 1999. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 126: 2589–2596.
- , , , , , , , , . 1998. Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A 95: 15735–15740.
- , , , , . 2007. Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell 18: 2264–2273.
- , . 2004. Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis. Bioessays 26: 857–869.
- , , , , , . 2003. Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40: 65–79.
- , , , , . 2005. Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. Dev Cell 9: 147–158.
- , , , , . 2005. Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 132: 1247–1260.
- , , . 2002. FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr Biol 12: 1807–1816.
- , , . 1996. Failure to detect connexin43 mutations in 38 cases of sporadic and familial heterotaxy. Circulation 94: 1909–1912.
- , , , , , , . 1997. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol 139: 1785–1792.
- , , , . 2002. Establishment of vertebrate left-right asymmetry. Nat Rev Genet 3: 103–113.
- . 2001. Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 34: 325–472.
- , , , . 2006. Nodal flow and the generation of left-right asymmetry. Cell 125: 33–45.
- , , , , , . 2005. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132: 1907–1921.
- , . 2001. A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediated intercellular communication in the lens. J Cell Biol 154: 197-216.
- . 2003. Motor protein control of ion flux is an early step in embryonic left-right asymmetry. Bioessays 25: 1002–1010.
- . 2005. Left-right asymmetry in embryonic development: a comprehensive review. Mech Dev 122: 3–25.
- , . 1998. Gap junctions are involved in the early generation of left-right asymmetry. Dev Biol 203: 90–105.
- , . 1999. Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node. Development 126: 4703–4714.
- , , , , . 1995. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82: 803–814.
- , , , , . 2002. Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning. Cell 111: 77–89.
- , , , . 1998. Maintenance of asymmetric nodal expression in Xenopus laevis. Dev Genet 23: 194–202.
- , . 1999. Gap junction signalling mediated through connexin-43 is required for chick limb development. Dev Biol 207: 380–392.
- , , , . 1997. Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb Bud. J Cell Biol 138: 1125–1137.
- . 2003. Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev 17: 2993–2997.
- , , , , . 2003. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 114: 61–73.
- , . 1999. Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285: 403–406.
- , . 2003. The developing human. Philadelphia: Saunders.
- , , , , , , , . 2006. Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. Dev Cell 11: 495–504.
- , , . 1997. Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human skin fibroblasts. Biochem Pharmacol 53: 1553–1557.
- , , , , , , , . 1998. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95: 829–837.
- , . 2007. Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Dev Biol 301: 447–463.
- , , , , . 2005. Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. Cell 121: 633–644.
- , , , . 2003. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 17: 3023–3028.
- , , , , , , , , . 1995. Cardiac malformation in neonatal mice lacking connexin43. Science 267: 1831–1834.
- , . 1997. Gap junctions equalize intracellular Na+ concentration in astrocytes. Glia 20: 299–307.
- , , . 2001. How to close a gap junction channel. Efficacies and potencies of uncoupling agents. Methods Mol Biol 154: 447–476.
- , , , , , , , , , , , , . 2000. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell 5: 35–47.
- , , , . 2003. Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol 256: 160–172.
- , , , . 2005. Inositol polyphosphates regulate zebrafish left-right asymmetry. Dev Cell 9: 133–145.
- , , , , , , . 2007. Cilia-driven leftward flow determines laterality in Xenopus. Curr Biol 17: 60–66.
- , , . 2004. Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis. Dev Biol 270: 163–185.
- , . 2006. Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. Nat Cell Biol 8: 271–277.
- , , , . 1985. Regulation of gap junctional conductance. Am J Physiol 248: 753–764.
- , . 2005. Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. Mol Biol Cell 16: 64–72.
- . 2005. Do we know anything about how left-right asymmetry is first established in the vertebrate embryo? J Mol Histol 36: 317–323.
- . 2006. The key to left-right asymmetry. Cell 127: 27–32.
- , , . 2005. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435: 172–177.
- , , , , , , , , , , , . 1999. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A 96: 11376–11381.
- , . 1999. Retinoic acid affects left-right patterning. Dev Biol 215: 332–342.
- , . 2001. Gating of retinal horizontal cell hemi gap junction channels by voltage, Ca2+, and retinoic acid. Mol Vis 7: 247–252.

1097-0177/asset/DVDY_left.gif?v=1&s=b87335326ab8ecd1f573539da0b5fa6abef26532)