Special Issue Reviews–A Peer Reviewed Forum
Building it up and taking it down: The regulation of vertebrate ciliogenesis
Version of Record online: 24 APR 2008
Copyright © 2008 Wiley-Liss, Inc.
Special Issue: Special Focus on the Primary Cilium
Volume 237, Issue 8, pages 1972–1981, August 2008
How to Cite
Santos, N. and Reiter, J. F. (2008), Building it up and taking it down: The regulation of vertebrate ciliogenesis. Dev. Dyn., 237: 1972–1981. doi: 10.1002/dvdy.21540
- Issue online: 23 JUL 2008
- Version of Record online: 24 APR 2008
- Manuscript Accepted: 25 FEB 2008
- Sandler Family Supporting Foundation
- Burroughs Wellcome Fund
- NIH. Grant Number: R01AR054396
- von Hippel-Lindau;
Primary cilia project from the surface of most vertebrate cells, and function in sensation and signaling during both development and adult tissue homeostasis. Mounting evidence links ciliary defects with a wide variety of diseases, underscoring the importance of understanding how these dynamic organelles are assembled and maintained. However, despite their physiological and clinical relevance, the logic and machinery that regulate ciliogenesis remain largely enigmatic. Here, we summarize emerging data that connect the assembly and disassembly of the primary cilium to cell cycle progression and we examine how determinants of cell architecture, including the planar cell polarity pathway, may regulate ciliogenesis. Additionally, identification of the genes underlying diverse ciliopathies in human patients is shedding light on the regulation of the formation of this complex organelle. Developmental Dynamics 237:1972–1981, 2008. © 2008 Wiley-Liss, Inc.