SPARC is expressed by macroglia and microglia in the developing and mature nervous system



Distribution of the matricellular protein, SPARC/osteonectin (green), in the dentate gyrus of the postnatal mouse. SPARC expression partially overlaps with the radial glial markers, nestin (red, top panel) and brain-lipid binding protein (red, bottom panel; DAPI nuclear counterstain, blue). See Vincent et al., Developmental Dynamics 237:1449–1462, 2008. © 2008 Wiley-Liss, Inc.