Special Issue Reviews–A Peer Reviewed Forum
Development of the corneal stroma, and the collagen–proteoglycan associations that help define its structure and function
Article first published online: 3 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
Special Issue: Special Focus on the Extracellular Matrix, in Memory of Dr. Elizabeth D. Hay
Volume 237, Issue 10, pages 2607–2621, October 2008
How to Cite
Quantock, A. J. and Young, R. D. (2008), Development of the corneal stroma, and the collagen–proteoglycan associations that help define its structure and function. Dev. Dyn., 237: 2607–2621. doi: 10.1002/dvdy.21579
- Issue published online: 24 SEP 2008
- Article first published online: 3 JUN 2008
- Manuscript Accepted: 10 APR 2008
- Biotechnology and Biological Sciences Research Council. Grant Number: BBS/B/10994
- Engineering and Physical Sciences Research Council. Grant Number: EP/F034970/1
- corneal development;
The cornea of the eye is a unique, transparent connective tissue. It is comprised predominantly of collagen fibrils, remarkably uniform in diameter and regularly spaced, organized into an intricate lamellar array. Its establishment involves a precisely controlled sequence of developmental events in which the embryonic cornea undergoes major structural transformations that ultimately determine tissue form and function. In this article, we will review corneal developmental dynamics from a structural perspective, consider the roles and interrelationships of collagens and proteoglycans, and comment on contemporary concepts and current challenges pertinent to developmental processes that result in an optically clear, mature cornea. Developmental Dynamics 237:2607–2621, 2008. © 2008 Wiley-Liss, Inc.