Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
Article first published online: 3 JUN 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 7, pages 1799–1811, July 2008
How to Cite
Solberg, N., Machon, O. and Krauss, S. (2008), Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev. Dyn., 237: 1799–1811. doi: 10.1002/dvdy.21586
- Issue published online: 20 JUN 2008
- Article first published online: 3 JUN 2008
- Manuscript Accepted: 20 APR 2008
- Norwegian Center for Stemcell Research. Grant Number: 32065
- dentate gyrus;
- Wnt signaling;
Canonical Wnt signaling is crucial for the correct development of both cortical and hippocampal structures in the dorsal telencephalon. In this study, we examined the role of the canonical Wnt signaling in the dorsal telencephalon of mouse embryos at defined time periods by inhibition of the pathway with ectopic expression of Dkk1. Transgenic mice with the D6-driven Dkk1 gene exhibited reduced canonical Wnt signaling in the cortex and hippocampus. As a result, all hippocampal fields were reduced in size. Neurogenesis in the dentate gyrus was severely reduced both in the premigratory and migratory progenitor pool. The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages. Developmental Dynamics 237:1799–1811, 2008. © 2008 Wiley-Liss, Inc.