WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth
Article first published online: 22 MAY 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 6, page spc1, June 2008
How to Cite
Potok, M. A., Cha, K. B., Hunt, A., Brinkmeier, M. L., Leitges, M., Kispert, A. and Camper, S. A. (2008), WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev. Dyn., 237: spc1. doi: 10.1002/dvdy.21603
- Issue published online: 22 MAY 2008
- Article first published online: 22 MAY 2008
- NIH. Grant Numbers: R37-HD30428, R01-HD34283
- Cellular and Molecular Approaches to Systems and Integrative Biology. Grant Number: 2-T32-BM0832213
- Medical Scientist Training Program. Grant Number: GM07863
- Cited By
WNT5A deficiency causes pituitary dysmorphology and ectopic melanotrope differentiation. Immunohistochemistry for prohormone convertase 2 (PC2) marks melanotrope cells, which are normally confined to the intermediate lobe of the pituitary gland. Wnt5a mutant mice contain ectopic melanotropes in a region of dysmorphology adjacent to the intermediate lobe. We show a coronal section from an e18.5 Wnt5a mutant pituitary gland stained with a PC2 specific antibody, developed with the chromagen diaminobenzidine, and counterstained with hematoxylin. The image is artistically arranged as a mirror image duplication with the dorsal aspect of the pituitary facing the outer edges and the ventral aspect towards the center plane. See Potok et al., Developmental Dynamics 237:1006–1020, 2008. © 2008 Wiley-Liss, Inc.