Drs. Pistocchi and Sordino contributed equally to this work.
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A peek inside the neurosecretory brain through Orthopedia lenses
Article first published online: 26 AUG 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 9, pages 2295–2303, September 2008
How to Cite
Del Giacco, L., Pistocchi, A., Cotelli, F., Fortunato, A. E. and Sordino, P. (2008), A peek inside the neurosecretory brain through Orthopedia lenses. Dev. Dyn., 237: 2295–2303. doi: 10.1002/dvdy.21668
- Issue published online: 26 AUG 2008
- Article first published online: 26 AUG 2008
- Manuscript Accepted: 19 JUN 2008
- hypothalamic nuclei;
- dopamine, DA
The wealth of expression and functional data presented in this overview discloses the homeogene Orthopedia (Otp) as critical for the development of the hypothalamic neuroendocrine system of vertebrates. Specifically, the results depict the up-to-date portrait of the regulation and functions of Otp. The development of neuroendocrine nuclei relies on Otp from fish to mammals, as demonstrated for several peptide and hormone releasing neurons. Additionally, the activity of Otp is essential for the induction of the dopaminergic phenotype in the hypothalamus of vertebrates. Recent insights into the pathways required for Otp regulation have revealed the implication of the main extracellular signals acting during hypothalamic development. Alterations in these pathways are involved in several neuronal disorders, and the resultant downstream misregulation of Otp might impair the development of the hypothalamus, and be therefore responsible for the neuroendocrine dysfunctions that typify these diseases. Developmental Dynamics 237:2295–2303, 2008. © 2008 Wiley-Liss, Inc.