Fluid dynamics of nodal flow and left–right patterning in development

Authors

  • Julyan H.E. Cartwright,

    Corresponding author
    1. Instituto Andaluz de Ciencias de la Tierra, CSIC–Universidad de Granada, Campus Fuentenueva, Granada, Spain
    • Instituto Andaluz de Ciencias de la Tierra, CSIC–Universidad de Granada, Campus Fuentenueva, Granada E-18071, Spain
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  • Nicolas Piro,

    1. ICFO-Institut de Ciencies Fotoniques, Mediterranean Technology Park, Castelldefels (Barcelona), Spain
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  • Oreste Piro,

    1. Dept de Física e Instituto de Física Interdisciplinar, y Sistemas Complejos IFISC (CSIC-UIB), Universitat de les Illes Balears, Palma de Mallorca, Spain
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  • Idan Tuval

    Corresponding author
    1. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom
    • Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK
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Abstract

The manner in which the nodal flow determines the breaking of left–right symmetry during development is a beautiful example of the application of fluid dynamics to developmental biology. Detailed understanding of this crucial developmental process has greatly advanced by the transfer of ideas between these two disciplines. In this article, we review our and others' work on applying fluid dynamics and dynamical systems to the problem of left–right symmetry breaking in vertebrates. Developmental Dynamics 237:3477–3490, 2008. © 2008 Wiley-Liss, Inc.

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