Patterns & Phenotypes
SSAO/VAP-1 protein expression during mouse embryonic development
Article first published online: 26 AUG 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 9, pages 2585–2593, September 2008
How to Cite
Valente, T., Solé, M. and Unzeta, M. (2008), SSAO/VAP-1 protein expression during mouse embryonic development. Dev. Dyn., 237: 2585–2593. doi: 10.1002/dvdy.21682
- Issue published online: 26 AUG 2008
- Article first published online: 26 AUG 2008
- Manuscript Accepted: 1 JUL 2008
- FIS, Ministerio de Sanidad, Instituto de Salud Carlos III, Spain. Grant Number: 03/0243
- smooth muscle cells;
- cartilage development;
- vascular cells
SSAO/VAP-1 is a multifunctional enzyme depending on in which tissue it is expressed. SSAO/VAP-1 is present in almost all adult mammalian tissues, especially in highly vascularised ones and in adipocytes. SSAO/VAP-1 is an amine oxidase able to metabolise various endogenous or exogenous primary amines. Its catalytic activity can lead to cellular oxidative stress, which has been implicated in several pathologies (atherosclerosis, diabetes, and Alzheimer's disease). The aim of this work is to achieve a study of SSAO/VAP-1 protein expression during mouse embryogenesis. Our results show that SSAO/VAP-1 appears early in the development of the vascular system, adipose tissue, and smooth muscle cells. Moreover, its expression is strong in several epithelia of the sensory organs, as well as in the development of cartilage sites. Altogether, this suggests that SSAO/VAP-1 enzyme could be involved in the differentiation processes that take place during embryonic development, concretely in tissue vascularisation. Developmental Dynamics 237:2585–2593, 2008. © 2008 Wiley-Liss, Inc.