Renal glomerulogenesis in medaka fish, Oryzias latipes
Article first published online: 26 AUG 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 9, pages 2342–2352, September 2008
How to Cite
Fedorova, S., Miyamoto, R., Harada, T., Isogai, S., Hashimoto, H., Ozato, K. and Wakamatsu, Y. (2008), Renal glomerulogenesis in medaka fish, Oryzias latipes. Dev. Dyn., 237: 2342–2352. doi: 10.1002/dvdy.21687
- Issue published online: 26 AUG 2008
- Article first published online: 26 AUG 2008
- Manuscript Accepted: 1 JUN 2008
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science Postdoctoral Fellowship for Foreign Researchers. Grant Number: FY2004 No. P 04169
- 3D image;
- animal model;
We provide an overview of glomerulogenesis in medaka from the embryo to the adult by means of in situ hybridization with the wt1 gene as a marker as well as histology and three-dimensional images. The pronephric glomus starts to develop in the intermediate mesoderm during early somitogenesis, is completed before hatching, and persists throughout the lifetime of the fish. Within 5 days after hatching, mesonephric glomerulus formation begins in the caudomedial end of the pronephric sinus and duct area. The number of glomeruli reaches approximately 200–300 in each kidney within 2 months after hatching. wt1 expression during nephron maturation served as a marker for the formation of the mesenchymal condensate and the nephrogenic body. Existence of mesenchymal condensates and persistence of wt1 expression in the adult kidney suggest that the mesonephros retains precursor cells that may be capable of contributing to neoglomerulogenesis during adulthood. Developmental Dynamics 237:2342–2352, 2008. © 2008 Wiley-Liss, Inc.