Patterns & Phenotypes

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Development of lymphatic vessels in mouse embryonic and early postnatal hearts

  1. Michał Juszyński1,†,
  2. Bogdan Ciszek2,†,
  3. Emilia Stachurska1,†,
  4. Anna Jabłońska1,†,
  5. Anna Ratajska1,†,*

Article first published online: 24 SEP 2008

DOI: 10.1002/dvdy.21693

Issue

Developmental Dynamics

Developmental Dynamics

Special Issue: Special Focus on the Extracellular Matrix, in Memory of Dr. Elizabeth D. Hay

Volume 237, Issue 10, pages 2973–2986, October 2008

Additional Information

How to Cite

Juszyński, M., Ciszek, B., Stachurska, E., Jabłońska, A. and Ratajska, A. (2008), Development of lymphatic vessels in mouse embryonic and early postnatal hearts. Dev. Dyn., 237: 2973–2986. doi: 10.1002/dvdy.21693

Author Information

  1. 1

    Department of Pathological Anatomy, Medical University of Warsaw, Poland

  2. 2

    Department of Anatomy, Medical University of Warsaw, Poland

  1. †

    All authors contributed equally to this manuscript.

*Department of Pathological Anatomy, Medical University of Warsaw, Poland

  1. †

    All authors contributed equally to this manuscript.

Publication History

  1. Issue published online: 24 SEP 2008
  2. Article first published online: 24 SEP 2008
  3. Manuscript Accepted: 7 JUL 2008

Funded by

  • Polish Ministry of Science and Higher Education. Grant Number: 2 P05A 111 28
  • Medical University of Warsaw. Grant Number: 1M11/W1

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Keywords:

  • lymphangiogenesis;
  • Lyve-1;
  • prox-1;
  • mouse embryonic heart;
  • heart development;
  • lymphatic vessels;
  • collecting lymphatics

Abstract

We aimed to study the spatiotemporal pattern of lymphatic system formation in the embryonic and early postnatal mouse hearts. The first sign of the development of lymphatics are Lyve-1–positive cells located on the subepicardial area. Strands of Lyve-1–positive cells occur first along the atrioventricular sulcus of the diaphragmatic surface and then along the great arteries. Lumenized tubules appear, arranged in rows or in a lattice. They are more conspicuous in dorsal atrioventricular junction, along the major venous and coronary artery branches and at the base of the aorta and the pulmonary trunk extending toward the heart apex. At later stages, some segments of the lymphatic vessels are partially surrounded by smooth muscle cells. Possible mechanisms of lymphangiogenesis are: addition of Lyve-1–positive cells to the existing tubules, elongation of the lymphatic lattice, sprouting and coalescence of tubules. We discuss the existence of various subpopulations of endothelial cells among the Lyve-1–positive cells. Developmental Dynamics 237:2973–2986, 2008. © 2008 Wiley-Liss, Inc.

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